Wnt proteins initiate three distinct signaling pathways− the canonical, non-canonical or
planar cell polarity (PCP), and Wnt-Ca2+ pathway. The members of the dishevelled …

Glioblastomas are the most aggressive and lethal primary astrocytic tumors of the central
nervous system. They account for 60% to 70% of all gliomas and the majority are diagnosed …

Glioblastoma is the most common and aggressive brain tumor, with a subpopulation of stem‐
like cells thought to mediate its recurring behavior and therapeutic resistance. The epithelial …

Temozolomide (TMZ) is currently one of the first‑line drugs used for the treatment of high‑
grade gliomas. However, TMZ resistance results in unsatisfactory therapeutic effects in …

Canonical Wnt signaling is a highly conserved pathway with a prominent role in
embryogenic development, adult tissue homeostasis, cell polarization, stem cell biology, cell …

Aryl hydrocarbon receptor (AHR) is a ligand‑activated transcription factor, whose canonical
pathway mainly regulates the genes involved in xenobiotic metabolism. However, it can also …

Aims Our previous study has demonstrated that β-catenin pathway was abnormally activated
in nasopharyngeal carcinoma (NPC). The purposes of the present study are to investigate …

Astrocytomas are one of the most vascularized types tumor in human cancers. Micro‑
vascular proliferation is an important factor for the classification of astrocytoma …

Simple Summary Gliomas are deleterious central nervous system tumors that harbor cellular
heterogeneity and infiltrative capabilities. They are biologically aggressive and highly …

Key regulators of the Wnt signalling, DVL 1, DVL 2 and DVL 3, in astrocytomas of different
malignancy grades were investigated. Markers for DVL 1, DVL 2 and DVL 3 were used to …