The persistence of airway hyperresponsiveness (AHR) and serotonergic enhancement of
airway smooth muscle (ASM) contraction induced by ozone (O3) plus allergen has not been …

There is mounting evidence that 5-hydroxytryptamine (5-HT) plays a role in asthma.
However, scarce information exists about the pulmonary expression of 5-HT receptors and …

Background Chronic obstructive pulmonary disease (COPD) arises from an interaction
between genetic host factors and environmental exposures (mainly cigarette smoke (CS)) …

An increased bronchoconstrictor response is a hallmark in the progression of obstructive
airway diseases. Acetylcholine and 5-hydroxytryptamine (5-HT, serotonin) are the major …

In 2010 over 200 articles were published in Clinical and Experimental Allergy including
editorials, reviews, opinion articles, letters, book reviews and of course at the heart of the …

Several contractile mediators involved in the antigen-induced airway obstruction have been
identified, but the role of 5-HT (5-hydroxytryptamine or serotonin) has been scantily …

Extracellular ATP promotes an indirect contraction of airway smooth muscle via the
secondary release of thromboxane A 2 (TXA 2) from airway epithelium. Our aim was to …

Epidemiological and clinical studies suggest that asthma is associated with adverse
cardiovascular outcomes, but its mechanism is uncertain. 5-Hydroxytryptamine (5-HT) is a …

Sažetak Asthma is a common but complex chronic inflammatory disease of the respiratory
airways. Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are associated with …

Human genome-wide association studies have identified over 50 loci associated with
pulmonary function and related phenotypes, yet follow-up studies to determine causal genes …