Research on the neural substrates of drug reward, withdrawal and relapse has yet to be
translated into significant advances in the treatment of addiction. One potential reason is that …

Objective: To review deficits in emotional processing and social cognition potentially
contributing to the dysfunctional emotion regulation and difficulties with interpersonal …

Although gray matter (GM) damages caused by long term and excessive alcohol
consumption have long been reported, the structural neuroimaging findings on alcohol-use …

Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

Alcohol misuse and addiction are major international public health issues. Addiction can be
characterized as a disorder of aberrant neurocircuitry interacting with environmental, genetic …

The pioneering work by von Economo in 1925 on the cytoarchitectonics of the cerebral
cortex revealed a specialized and unique cell type in the adult human fronto-insular (FI) and …

The human neural correlates of social rejection have attracted significant research interest,
but remain subject to vigorous debate. Specifically, it has been proposed that a matrix of …

Background Convergent preclinical and clinical evidence has linked the anterior insula to
impulsivity and alcohol-associated compulsivity. The anterior insula is functionally …

Over the last 10 years, rates of alcohol use disorder (AUD) have increased in women by
84% relative to a 35% increase in men. Rates of alcohol use and high‐risk drinking have …

The anterior insular cortex plays a key role in the representation of interoceptive effects of
drug and natural rewards and their integration with attention, executive function, and …