Background The use of anthracycline chemotherapy is limited by the occurrence of
cardiotoxicity. In an effort to prevent this cardiotoxicity, different anthracycline derivates have …

Introduction Previous studies in metastatic soft tissue sarcomas (STS) showed that synovial
sarcomas tend to have better survival rates and a higher chemosensitivity than other STS …

Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a
heterogenous mix of clinical and pathologic characteristics. STS can develop from fat …

Soft tissue sarcomas (STS) are rare malignancies of mesenchymal cell origin that display a
heterogenous mix of clinical and pathologic characteristics. STS can develop from fat …

PURPOSE: A total of 2,185 patients with advanced soft tissue sarcomas who had been
treated in seven clinical trials investigating the use of doxorubicin-or epirubicin-containing …

Purpose Palifosfamide is the active metabolite of ifosfamide and does not require prodrug
activation, thereby avoiding the generation of toxic metabolites. The PICASSO III trial …

CAELYX®/DOXIL®, pegylated liposomal doxorubicin, has shown antitumour activity and
reduced toxicity compared with standard doxorubicin in other tumour types. In this …

BACKGROUND: Adult patients with advanced soft tissue sarcomas (STS) are generally
treated similarly, regardless of great differences between STS subtypes, disease …

Purpose To assess the efficacy of the marine-derived alkaloid ecteinascidin 743 (ET-743) in
patients with soft tissue sarcomas that progressed despite prior conventional chemotherapy …

Epirubicin is the 4′ epimer of the anthracycline antibiotic doxorubicin, and has been used
alone or in combination with other cytotoxic agents in the treatment of a variety of …