[HTML][HTML] Pathogenic mechanisms underlying idiopathic pulmonary fibrosis

BJ Moss, SW Ryter, IO Rosas - Annual Review of Pathology …, 2022 - annualreviews.org
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

[HTML][HTML] COVID-19 and oxidative stress

BV Chernyak, EN Popova, AS Prikhodko… - Biochemistry …, 2020 - Springer
Pathogenesis of the novel coronavirus infection COVID-19 is the subject of active research
around the world. COVID-19 caused by the SARS-CoV-2 is a complex disease in which …

Developmental pathways in the pathogenesis of lung fibrosis

D Chanda, E Otoupalova, SR Smith, T Volckaert… - Molecular aspects of …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

A hypothesis for pathobiology and treatment of COVID‐19: the centrality of ACE1/ACE2 imbalance

K Sriram, PA Insel - British journal of pharmacology, 2020 - Wiley Online Library
Angiotensin Converting Enzyme2 is the cell surface binding site for the coronavirus SARS‐
CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐and …

[HTML][HTML] Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

[HTML][HTML] Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function

BLM Hogan, CE Barkauskas, HA Chapman, JA Epstein… - Cell stem cell, 2014 - cell.com
Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

[HTML][HTML] Role of interleukins in the pathogenesis of pulmonary fibrosis

YX She, QY Yu, XX Tang - Cell Death Discovery, 2021 - nature.com
Interleukins, a group of cytokines participating in inflammation and immune response, are
proved to be involved in the formation and development of pulmonary fibrosis. In this article …

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo

M Lehmann, M Korfei, K Mutze, S Klee… - European …, 2017 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor prognosis and
limited therapeutic options. The incidence of IPF increases with age, and ageing-related …

Myofibroblasts

B Hinz - Experimental eye research, 2016 - Elsevier
Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or
damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction …

The role of myofibroblasts in wound healing

B Hinz - Current research in translational medicine, 2016 - Elsevier
The importance of proper skin wound healing becomes evident when our body's repair
mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair …