The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by
ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting …

Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects
of extracellular ATP are mediated by plasma membrane receptors named P2 receptors …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …

Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a
process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Extracellular nucleotides have been recognized as important mediators of activation,
triggering multiple responses via plasma membrane receptors known as P2 receptors. P2 …

The study of P2X receptors has long been handicapped by a poverty of small-molecule tools
that serve as selective agonists and antagonists. There has been progress, particularly in …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …