Mitochondrial dysfunction plays a primary role in neurodevelopmental anomalies and
neurodegeneration of Down syndrome (DS) subjects. For this reason, targeting …

Down syndrome (DS) is the most common chromosomal abnormality and leads to
intellectual disability, increased risk of cardiac defects, and an altered immune response …

Down syndrome (DS) is a common genetic condition in which a person is born with an extra
copy of chromosome 21. Intellectual disability is the most common characteristic of DS. N6 …

Background: Deficits in mitochondrial function and oxidative stress play pivotal roles in
Down syndrome (DS) and Alzheimer's disease (AD) and these alterations in mitochondria …

The regulation of mitochondrial biogenesis is under the control of nuclear genes including
the master Mitochondrial Transcription Factor A (TFAM). Recent evidence suggests that the …

Oxidative stress (OS) and mitochondrial dysfunction (MD) have been extensively studied
and defined as therapeutic targets in Down syndrome (DS). Though originally associated to …

Children show a higher incidence of leukaemia compared with young adolescents, yet their
cells are less damaged because of their young age. Children with Down syndrome (DS) …

Brain diseases including Down syndrome (DS/TS21) are known to be characterized by
changes in cellular metabolism. To adequately assess such metabolic changes during …

The number of active ribosomal genes (AcRG) was evaluated in 172 carriers of
chromosomal abnormalities (CA) such as Down's syndrome (DS), Robertsonian …

For many decades, neurons have been the central focus of studies on the mechanisms
underlying the neurodevelopmental and neurodegenerative aspects of Down syndrome …