Targeting apoptosis to overcome chemotherapy resistance

E Dogan, HG Kara, B Kosova… - Exon Publications, 2022 - exonpublications.com
Chemotherapy resistance is a major limiting factor for the extensive use of chemotherapeutic
drugs in cancer treatment. Despite the large number of newly discovered medications …

Multifunctional nanoplatforms as a novel effective approach in photodynamic therapy and chemotherapy, to overcome multidrug resistance in cancer

M Majerník, R Jendželovský, J Vargová… - Pharmaceutics, 2022 - mdpi.com
It is more than sixty years since the era of modern photodynamic therapy (PDT) for cancer
began. Enhanced selectivity for malignant cells with a reduced selectivity for non-malignant …

Impact of the central atom and halido ligand on the structure, antiproliferative activity and selectivity of half-sandwich Ru (II) and Ir (III) complexes with a 1, 3, 4 …

R Křikavová, M Romanovová, Z Jendželovská… - Dalton …, 2023 - pubs.rsc.org
Half-sandwich complexes [Ru (η6-pcym)(L1) X] PF6 (1, 3) and [Ir (η5-Cp*)(L1) X] PF6 (2, 4)
featuring a thiadiazole-based ligand L1 (2-(furan-2-yl)-5-(pyridin-2-yl)-1, 3, 4-thiadiazole) …

Insight into the web of stress responses triggered at gene expression level by porphyrin-PDT in HT29 human colon carcinoma cells

M Dobre, R Boscencu, IV Neagoe, M Surcel, E Milanesi… - Pharmaceutics, 2021 - mdpi.com
Photodynamic therapy (PDT), a highly targeted therapy with acceptable side effects, has
emerged as a promising therapeutic option in oncologic pathology. One of the issues that …

Short-term hypoxia in cells induces expression of genes which are enhanced in stressed cells

I Peciuliene, E Jakubauskiene, L Vilys, R Zinkeviciute… - Genes, 2022 - mdpi.com
All living organisms must respond to, and defend against, environmental stresses.
Depending on the extent and severity of stress, cells try to alter their metabolism and adapt …

Comparison of cytotoxic, genotoxic, and DNA-protective effects of skyrin on cancerous vs. non-cancerous human cells

T Zajičková, E Horváthová, S Kyzek, E Šályová… - International Journal of …, 2022 - mdpi.com
Secondary metabolites as a potential source of anticancer therapeutics have been the
subject of many studies. Since hypericin, a metabolite isolated from Hypericum perforatum …

[PDF][PDF] Vplyv proteínu p53 na účinok skyrínu v bunkách ľudského kolorektálneho karcinómu

I Barčáková, Z Jendželovská… - DROBNICOV … - dm2023.vedaazivot.sk
Skyrín je sekundárny metabolit viacerých húb a lišajníkov, patriaci medzi bisantrachinóny.
Napriek tomu, že o jeho biologickej aktivite existuje len málo poznatkov, v poslednom …