An estimated 30–40% of cancers can be prevented through changes in modifiable lifestyle
and environmental risk factors known to be associated with cancer incidence. Despite this …

Suppression of antitumor immune responses is one of the main mechanisms by which tumor
cells escape from destruction by the immune system. Myeloid-derived suppressor cells …

The microbiota comprises the microorganisms that live in close contact with the host, with
mutual benefit for both counterparts. The contribution of the gut microbiota to the emergence …

Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …

Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of
people worldwide. However recent studies have indicated that niclosamide may have broad …

Genome sequencing and gene expression analyses of prostate tumours have highlighted
the potential importance of genetic and epigenetic changes observed in WNT signalling …

One in seven men in North America is expected to be diagnosed with prostate cancer (PCa)
during their lifetime (,). While a wide range of treatment options including surgery, radiation …

Background The systemic immune-inflammation index (SII) is a novel biomarker to predict
the prognosis of some malignant tumors based on neutrophil, platelet, and lymphocyte …

Background Castration-resistant prostate cancer (CRPC) occurs when prostate cancer
(CaP) progresses under therapy-induced castrate conditions. Several mechanisms have …

Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay
of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens …