Pathological heart injuries such as myocardial infarction induce adverse ventricular
remodeling and progression to heart failure owing to widespread cardiomyocyte death. The …

Heart disease is the leading cause of mortality worldwide. Due to the limited proliferation
rate of mature cardiomyocytes, adult mammalian hearts are unable to regenerate damaged …

Ischemic heart disease remains the primary cause of morbidity and mortality worldwide.
Despite significant advancements in pharmacological and revascularization techniques in …

Abstract α-Bisabolol, an unsaturated monocyclic sesquiterpene alcohol, is a common
ingredient in many pharmaceuticals and personal care products (PPCPs). Despite being …

Background During development a pool of precursors form a heart with atrial and ventricular
chambers that exhibit distinct transcriptional and electrophysiological properties. Normal …

As two members of the basic helix-loop-helix family of transcription factors, HAND1 and
HAND2 are both required for the embryonic cardiogenesis and postnatal ventricular …

Background Transcription factors HAND1 and HAND2 (HAND1/2) play significant roles in
cardiac organogenesis. Abnormal expression and deficiency of HAND1/2 result in severe …

The word estrogen is commonly used to refer to 17β-estradiol (E2) due to its physiological
relevance and predominance during reproductive growth. Estrogens are sex steroid …

During embryogenesis, epithelial organization is the prerequisite for organogenesis, in
particular, for establishing the tubular structure. Recent studies provided hints about …

Hox genes orchestrate the segmental specification of the muscular circulatory system in
invertebrates but it has not proven straightforward to decipher segmental parallels in the …