The dual role of innate immune response in acetaminophen-induced liver injury

T Yang, H Wang, X Wang, J Li, L Jiang - Biology, 2022 - mdpi.com
Simple Summary An injury to the liver caused by a drug or its metabolites is referred to as
drug-induced liver injury (DILI). The clinical manifestations of DILI are varied, and it may …

Targeting innate immune responses to attenuate acetaminophen-induced hepatotoxicity

J Wang, L Zhang, Q Shi, B Yang, Q He, J Wang… - Biochemical …, 2022 - Elsevier
Acetaminophen (APAP) hepatotoxicity is an important cause of acute liver failure, resulting
in massive deaths in many developed countries. Currently, the metabolic process of APAP in …

The immunological mechanisms and therapeutic potential in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Q Li, F Chen, F Wang - Cell & Bioscience, 2022 - Springer
Acute liver failure caused by drug overdose is a significant clinical problem in developed
countries. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, but its …

Celastrol-loaded biomimetic nanodrug ameliorates APAP-induced liver injury through modulating macrophage polarization

J Zheng, N Yang, Y Wan, W Cheng, G Zhang… - Journal of Molecular …, 2023 - Springer
Drug-induced liver injury (DILI) is a major concern in clinical treatment as well as
postmarketing surveillance, showing an urgent requirement for the development of …

Naringin alleviates a cetaminophen‐induced acute liver injury by activating Nrf2 via CHAC2 upregulation

X Zhai, T Dai, Z Chi, Z Zhao, G Wu… - Environmental …, 2022 - Wiley Online Library
Severe acetaminophen (APAP)‐induced hepatic damage is the second most common
cause for hepatic transplantation. Clinically, hepatic damage caused by APAP is treated …

[HTML][HTML] A dual role of inflammation in acetaminophen-induced liver injury

L Xu, H Wang - Liver Research, 2023 - Elsevier
In many affluent nations, acetaminophen (APAP) overdose is the leading cause of drug-
induced acute liver failure. The process of APAP-induced liver injury (AILI) is intimately tied …

Sumc (Rhus coriaria L.) fruit ameliorates paracetamol-induced hepatotoxicity

T El-Elimat, BK Al-Tal, NA Al-Sawalha, M Alsaggar… - Food Bioscience, 2023 - Elsevier
Abstract Sumac [Rhus coriaria L.(Anacardiaceae)] is a widely used spice in the Middle East.
In this study, the hepatoprotective effects of sumac fruit were evaluated using a rat model of …

[HTML][HTML] Targeting the sterile inflammatory response during acetaminophen hepatotoxicity with natural products

H Jaeschke, A Ramachandran - Toxicology letters, 2022 - ncbi.nlm.nih.gov
The sterile inflammatory response observed after hepatic necrosis caused by an
acetaminophen (APAP) overdose has been a controversial topic for years. In a recent …

Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver

SY Alabbas, R Giri, I Oancea, J Davies… - Journal of …, 2023 - Wiley Online Library
Abstract Background and Aim Prevention of liver failure arising from accidental or deliberate
paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite …

Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats: Abelmoschus esculentus in acute acetaminophen …

H Kocabey, M Bekdas, A Cetinkaya… - Indian Journal of …, 2023 - or.niscpr.res.in
Acetaminophen (APAP) is one of the most regularly utilized medicines in children. When
administered at the recommended doses, it is a safe medication. However, oxidative stress …