Peptides have been extensively utilized to construct nanomaterials that display targeted
structure through hierarchical assembly. The self-assembly of both rationally designed …

Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are …

The amylome is the universe of proteins that are capable of forming amyloid-like fibrils. Here
we investigate the factors that enable a protein to belong to the amylome. A major factor is …

Liquid-liquid phase separation is emerging as a crucial phenomenon in several
fundamental cell processes. A range of eukaryotic systems exhibit liquid condensates …

Fabrication of ultrasmall functional machines and their integration within ultrasmall areas or
volumes can be useful for creation of novel technologies. The ultimate goal of the …

Two major pathways degrade most cellular proteins in eukaryotic cells: the ubiquitin–
proteasome system (UPS), which usually degrades the majority of proteins, and autophagy …

Aberrant phase separation of globular proteins is associated with many diseases. Here, we
use a model protein system to understand how the unfolded states of globular proteins drive …