Type I interferons have been suspected for decades to have a crucial role in the
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …

Kidney involvement in patients with systemic lupus erythematosus—lupus nephritis (LN)—is
one of the most important and common clinical manifestations of this disease and occurs in …

This assessment by the Environmental Effects Assessment Panel (EEAP) of the Montreal
Protocol under the United Nations Environment Programme (UNEP) evaluates the effects of …

Cutaneous lupus erythematosus (CLE) is a disfiguring and poorly understood condition
frequently associated with systemic lupus. Previous studies suggest that nonlesional …

Background Observations with rituximab suggest B-cell independent mechanisms of
cutaneous lupus erythematosus (CLE) in systemic lupus erythematosus (SLE), especially …

IL-33, a nuclear alarmin released during cell death, exerts context-specific effects on
adaptive and innate immune cells, eliciting potent inflammatory responses. We screened …

Gasdermin E (GSDME)-mediated pyroptosis is induced in keratinocytes of UVB-challenged
skin. The role of GSDME in UVB-caused skin damage remains unknown. To explore the role …

The development of lupus nephritis is multifactorial involving genetic susceptibility,
environmental triggers and systemic inflammation. However, the role of resident kidney cells …

Polyurethane (PU) is a widely used polymer material that will age under prolonged
exposure to ultraviolet (UV) light, shortening the service life. Several methods have been …

Inflammation is a life-saving immune reaction occurring in response to invading pathogens.
Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading …