The foreign body response: emerging cell types and considerations for targeted therapeutics

B Yang, N Rutkowski, J Elisseeff - Biomaterials science, 2023 - pubs.rsc.org
The foreign body response (FBR) remains a clinical challenge in the field of biomaterials
due to its ability to elicit a chronic and sustained immune response. Modulating the immune …

Potential effects of biomaterials on macrophage function and their signalling pathways

F Zhu, S Wang, X Zhu, C Pang, P Cui, F Yang… - Biomaterials …, 2023 - pubs.rsc.org
The use of biomaterials in biomedicine and healthcare has increased in recent years.
Macrophages are the primary immune cells that induce inflammation and tissue repair after …

Construction of a layer-by-layer self-assembled rosemarinic acid delivery system on the surface of CFRPEEK implants for enhanced anti-inflammatory and …

S Zhao, X Zhou, J Dang, Y Wang, J Jiang… - Journal of Materials …, 2024 - pubs.rsc.org
Carbon fiber-reinforced polyether ether ketone (CFRPEEK) implants have attracted
widespread attention in the field of clinical bone defect repair. However, the surface …

Contribution of αβ T cells to macrophage polarization and MSC recruitment and proliferation on titanium implants

D Avery, L Morandini, M Gabriec, L Sheakley… - Acta Biomaterialia, 2023 - Elsevier
Physiochemical cues like topography and wettability can impact the inflammatory response
and tissue integration after biomaterial implantation. T cells are essential for …

CD4+ and CD8+ T cells reduce inflammation and promote bone healing in response to titanium implants

D Avery, L Morandini, L Sheakley, M Grabiec… - Acta Biomaterialia, 2024 - Elsevier
T cells are adaptive immune cells essential in pathogenic response, cancer, and
autoimmune disorders. During the integration of biomaterials with host tissue, T cells modify …

Development and characterization of MAO/PLA-nHA nanocomposite coatings on pure zinc for orthopedic applications

Q Chen, X Zhu, Y Jiang, L Yang, HH Liu… - Surface and Coatings …, 2024 - Elsevier
Zinc (Zn)-based medical alloys are considered to be a biodegradable material with great
potential. Hydroxyapatite (HA) can improve the osteogenic properties of Zn alloys, but its …

A review of non-biodegradable alloys implantation induced inflammatory and immune cell responses

L Xu, C Wei, L Deng, P Wang, W Zhong… - Journal of Alloys and …, 2023 - Elsevier
Metal implants are widely used in orthopedics and can improve the quality of life of injured
and diseased patients. However, many metal implants activate the local host immune …

The Role of Neutrophils in Biomaterial-Based Tissue Repair—Shifting Paradigms

AB Sousa, JN Barbosa - Journal of Functional Biomaterials, 2023 - mdpi.com
Tissue engineering and regenerative medicine are pursuing clinical valid solutions to repair
and restore function of damaged tissues or organs. This can be achieved in different ways …

On the way to increase osseointegration potential: Sequential SI-ATRP as promising tool for PEEK-based implant nano-engineering

K Ślusarczyk, M Flejszar, K Spilarewicz… - European Polymer …, 2024 - Elsevier
In the search of the ideal bone implant material, surface initiated atom transfer radical
polymerization (SI-ATRP) techniques were successfully employed to modify the …

[HTML][HTML] Immunotoxicity of stainless-steel nanoparticles obtained after 3D printing

E Olšovská, ML Mikušová, J Tulinská… - Ecotoxicology and …, 2024 - Elsevier
This study aims to investigate the in vitro effects of nanoparticles (NPs) produced during the
selective laser melting (SLM) of 316 L stainless steel metal powder on the immune response …