Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

The gasdermin (GSDM) superfamily has been demonstrated to consist of several important
molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this …

Sirtuin belongs to a family of coenzyme nicotinamide adenine dinucleotide (NAD+)-
dependent histone deacetylases, which could be classified as seven isoforms (SIRT1 …

Recent advances in glioblastoma (GB) research have shed light on the molecular
characteristics, the defected intracellular signaling pathways, and the genetic and epigenetic …

Background Glioma is a common malignant tumor worldwide. Sevoflurane (Sev) has been
reported to inhibit the metastasis of glioma cells, but the underlying molecular mechanism …

Background Studies have increasingly shown that carbamoyl phosphate synthetase 1
(CPS1) plays a vital role in the occurrence and development of human malignant disease …

The development of chemoresistance remains a significant barrier to treating NSCLC.
Alteration of cancer cell metabolism is an important mechanism for chemoresistance. This …

High levels of heme oxygenase (HO)-1 have been frequently reported in different human
cancers, playing a major role in drug resistance and regulation of cancer cell redox …

Mitochondrial sirtuins have diverse role specifically in aging, metabolism and cancer. In
cancer, these sirtuins play dichotomous role as tumor suppressor and promoter. Previous …