Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

Cervical cancer remains one of the leading causes of cancer death worldwide.
Immunotherapy is the most promising cancer therapeutics in recent years and has gain …

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway
induces innate immunity by activating the production of inflammatory cytokines and type I …

Summary γ-interferon-inducible protein-16 (IFI16), a key DNA sensor, triggers downstream
STING-dependent type I interferon (IFN-I) production and antiviral immunity. However, it is …

Programmed cell death (PCD) refers to cell death in a manner that depends on specific
genes encoding signals or activities. PCD includes apoptosis, pyroptosis, autophagy and …

Pattern recognition receptors (PRRs) recognize pathogen-associated as well as
endogenous damage-associated molecular patterns. Once ligand binding occurs, signaling …

Abstract Heart failure affects 2–3% of adult Western population. Prevalence of heart failure
with preserved left ventricular (LV) ejection fraction (HFpEF) increases. Studies suggest …

As an effective antimalarial drug, Dihydroartemisinin (DHA) is readily isolated from the
traditional Chinese medicine of Artemisia annua. DHA is not only an autophagy promoter …

Interleukin 18 (IL18) was originally identified as an inflammation-induced cytokine that is
secreted by immune cells. An increasing number of studies have focused on its non …