[HTML][HTML] Neuroinflammation as a key driver of secondary neurodegeneration following stroke?

SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair

T Shichita, H Ooboshi, A Yoshimura - Nature Reviews Neuroscience, 2023 - nature.com
The nervous and immune systems control whole-body homeostasis and respond to various
types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and …

[HTML][HTML] The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Neutrophil extracellular traps exacerbate ischemic brain damage

C Li, Y Xing, Y Zhang, Y Hua, J Hu, Y Bai - Molecular neurobiology, 2022 - Springer
Most acute strokes are ischemic, and subsequent neuroinflammation promotes further
damage leading to cell death but also plays a beneficial role by promoting cellular repair …

[HTML][HTML] Tat-NTS peptide protects neurons against cerebral ischemia-reperfusion injury via ANXA1 SUMOylation in microglia

H Zhou, L Yan, H Huang, X Li, Q Xia, L Zheng… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Recent studies indicate that microglial activation and the resulting inflammatory
response could be potential targets of adjuvant therapy for ischemic stroke. Many studies …

[HTML][HTML] Ischemic stroke, glucocorticoids, and remote hippocampal damage: a translational outlook and implications for modeling

NV Gulyaeva, MV Onufriev, YV Moiseeva - Frontiers in neuroscience, 2021 - frontiersin.org
Progress in treating ischemic stroke (IS) and its delayed consequences has been
frustratingly slow due to the insufficient knowledge on the mechanism. One important factor …

Signaling pathways in brain ischemia: Mechanisms and therapeutic implications

W Lin, XY Zhao, J Cheng, L Li, Q Jiang… - Pharmacology & …, 2023 - Elsevier
Ischemic stroke occurs when the arteries supplying blood to the brain are narrowed or
blocked, inducing damage to brain tissue due to a lack of blood supply. One effective way to …

Brothers in arms: platelets and neutrophils in ischemic stroke

F Denorme, JL Rustad… - Current opinion in …, 2021 - journals.lww.com
Platelet-neutrophil interactions significantly contribute to the pathophysiology of ischemic
stroke brain injury. Better understanding the mechanisms behind their formation and the …

[HTML][HTML] Mesenchymal stem cells: therapeutic mechanisms for stroke

Y Zhang, N Dong, H Hong, J Qi, S Zhang… - International Journal of …, 2022 - mdpi.com
Due to aging of the world's population, stroke has become increasingly prevalent, leading to
a rise in socioeconomic burden. In the recent past, stroke research and treatment have …

[HTML][HTML] Research progress on pyroptosis-mediated immune-inflammatory response in ischemic stroke and the role of natural plant components as regulator of …

K Yang, T Bao, J Zeng, S Wang, X Yuan… - Biomedicine & …, 2023 - Elsevier
Ischemic stroke (IS) is one of the leading causes of death and disability. Its pathogenesis is
not completely clear, and inflammatory cascade is one of its main pathological processes …