As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still
thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the …

Introduction 3. Discovery of NO 3.1. Nitric oxide and the Nobel prize 3.2. NO generation and
nitric oxide synthase 3.2. 1. eNOS 3.2. 2. iNOS 3.2. 3. nNOS 3.3. Nitrovasodilators 4. NO …

A current challenge in cellular signaling is to decipher the complex intracellular
spatiotemporal organization that any given cell type has developed to discriminate among …

In addition to long-term regulation of angiogenesis, angiogenic growth factor signalling
through nitric oxide (NO) acutely controls blood flow and haemostasis. Inhibition of this …

Background—Cyclic guanosine monophosphate (cGMP) is the common second messenger
for the cardiovascular effects of nitric oxide (NO) and natriuretic peptides, such as atrial or …

Diatomic ligand discrimination by soluble guanylyl cyclase (sGC) is paramount to
cardiovascular homeostasis and neuronal signaling. Nitric oxide (NO) stimulates sGC …

Soluble guanylate cyclase (sGC) is a heme-containing heterodimeric enzyme that generates
many molecules of cGMP in response to its ligand nitric oxide (NO); sGC thereby acts as an …

Rationale: Chronic obstructive pulmonary disease (COPD) is a major cause of death
worldwide. No therapy stopping progress of the disease is available. Objectives: To …

Sacubitril/valsartan (Sac/Val) is a recently approved drug that is commonly used for
treatment of heart failure. Several studies indicated that Sac/Val also regulated the secretion …

Cyclic nucleotides cAMP and cGMP are ubiquitous second messengers which regulate
myriads of functions in virtually all eukaryotic cells. Their intracellular effects are often …