Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance
mechanisms in autoreactive CD8 T cells. How autoimmune T cell populations arise and are …

Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β
cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

Summary Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-
producing β cells. A comprehensive picture of the changes during T1D development is …

The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered
relatively straightforward. Recently, however, there is increasing awareness that within this …

Descriptions of insulitis in human islets throughout the natural history of type 1 diabetes are
limited. We determined insulitis frequency (the percent of islets displaying insulitis to total …

Type 1 diabetes mellitus (T1DM) is caused by progressive autoimmune-mediated loss of
pancreatic β-cell mass via apoptosis. The onset of T1DM depends on environmental factors …