Breast cancer has become a common tumor worldwide which seriously endangers people's
health. Early diagnosis and treatment are particularly urgent in order to reduce the onset …

Folate is a B-vitamin with an important role in health and disease. The optimal folate status
with regard to human health remains controversial. A low intake of natural folate as well as …

Background: There is no study that has systematically investigated the breadth and validity
of the associations of folate and multiple health outcomes. We aimed to evaluate the …

Vitamin B micronutrients are essential regulators of one carbon metabolism that ensures
human health. Vitamin B9, or folate, lies at the heart of the folate cycle and converges with …

Epidemiological studies have reported inconsistent findings for the association between B
vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers …

Cancer cell metabolism differs significantly from the metabolism of non-transformed cells.
This altered metabolic reprogramming mediates changes in the uptake and use of nutrients …

The role of folate, a water-soluble B-vitamin, in cancer development and progression
remains highly controversial. The crux of the hotly debated issue is whether folic acid (the …

Drug repositioning, or the identification of new indications for known drugs, is a useful
strategy for drug discovery. In this study, we developed novel computational methods to …

Folate metabolism plays an essential role in tumor development. Various cancers display
therapeutic response to reagents targeting key enzymes of the folate cycle, but obtain …

Proper nutrition plays a major role in preventing diseases and, therefore, nutritional
interventions constitute crucial strategies in the field of Public Health. Nutrigenomics and …