Quantitative structure–activity relationships (QSAR) provides a model that link biological
activities of compounds to thier chemical stuctures and molecular docking study reveals the …

Toxoplasma gondii is an important opportunistic pathogen for immunocompromised patients
and responsible for toxoplasmic encephalitis, which is often lethal. Treatment for this …

Selecting suitable targets is the critical first step in drug discovery. However, for malaria and
dengue this is quite a challenging step due to a large number of available structures for …

Malaria continues to pose a serious global health threat, and artemisinin remains the core
drug for global malaria control. However, the situation of malaria resistance has become …

Malarial infection is a disease that has defied many therapeutic and chemopreventive
interventions due to persistent resistance to currently available drugs. This is driven by the …

Malaria management remains a challenge, due to the resistance of malaria parasites to
current antimalarial agents. This resistance consequently delays the global elimination of …

Plasmodium falciparum is the pathogen responsible for 90% of all malaria cases and is
associated with severe complications and the highest fatality rate. Plasmodium falciparum …

Rapidly increasing resistance to the currently available antimalarial drugs has drawn
attention globally for the search for more potent novel drugs with a high therapeutic index …

Plasmodial lactate dehydrogenase, key enzyme of anaerobic glycolysis, has been shown to
be a potential immunodiagnostic marker as well as a novel target for chemotherapy. We …

Antimalarial drug discovery has been facilitated by the development of various in vitro drug
susceptibility testing methods suitable for medium-throughput or high-throughput …