Vertebrate endoderm development and organ formation
The endoderm germ layer contributes to the respiratory and gastrointestinal tracts and to all
of their associated organs. Over the past decade, studies in vertebrate model organisms …
of their associated organs. Over the past decade, studies in vertebrate model organisms …
Cell and tissue engineering for liver disease
Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …
function, advances in liver physiology, stem cell biology and reprogramming, and the …
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
Adult somatic tissues have proven difficult to expand in vitro, largely because of the
complexity of recreating appropriate environmental signals in culture. We have overcome …
complexity of recreating appropriate environmental signals in culture. We have overcome …
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
Abstract The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled
receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as …
receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as …
[HTML][HTML] Direct reprogramming of human fibroblasts to functional and expandable hepatocytes
The generation of large numbers of functional human hepatocytes for cell-based
approaches to liver disease is an important and unmet goal. Direct reprogramming of …
approaches to liver disease is an important and unmet goal. Direct reprogramming of …
[HTML][HTML] Transcription factor binding dynamics during human ES cell differentiation
Pluripotent stem cells provide a powerful system to dissect the underlying molecular
dynamics that regulate cell fate changes during mammalian development. Here we report …
dynamics that regulate cell fate changes during mammalian development. Here we report …
Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
P Huang, Z He, S Ji, H Sun, D Xiang, C Liu, Y Hu… - nature, 2011 - nature.com
The generation of functional hepatocytes independent of donor liver organs is of great
therapeutic interest with regard to regenerative medicine and possible cures for liver …
therapeutic interest with regard to regenerative medicine and possible cures for liver …
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
K Furuyama, Y Kawaguchi, H Akiyama, M Horiguchi… - Nature …, 2011 - nature.com
The liver and exocrine pancreas share a common structure, with functioning units (hepatic
plates and pancreatic acini) connected to the ductal tree. Here we show that Sox9 is …
plates and pancreatic acini) connected to the ductal tree. Here we show that Sox9 is …
Assessing the hepatotoxicity of PFOA, PFOS, and 6: 2 Cl-PFESA in black-spotted frogs (Rana nigromaculata) and elucidating potential association with gut microbiota
H Lin, H Wu, F Liu, H Yang, L Shen, J Chen… - Environmental …, 2022 - Elsevier
Pollution caused by per-and polyfluoroalkyl substances (PFASs) has become a major global
concern. The association between PFAS-induced hepatotoxicity and gut microbiota in …
concern. The association between PFAS-induced hepatotoxicity and gut microbiota in …
[HTML][HTML] Organogenesis and development of the liver
K Si-Tayeb, FP Lemaigre, SA Duncan - Developmental cell, 2010 - cell.com
Embryonic development of the liver has been studied intensely, yielding insights that impact
diverse areas of developmental and cell biology. Understanding the fundamental …
diverse areas of developmental and cell biology. Understanding the fundamental …