Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …

The composition of the gut microbiome can control innate and adaptive immunity and has
emerged as a key regulator of tumor growth, especially in the context of immune checkpoint …

An immunosuppressive tumour microenvironment is a major obstacle in the control of
pancreatic and other solid cancers,–. Agonists of the stimulator of interferon g enes (STING) …

Notable advances have been achieved in the treatment of cancer since the advent of
immunotherapy, and immune checkpoint inhibitors have shown clinical benefit across a …

Activation of the stimulator of interferon gene (STING) pathway within the tumor
microenvironment has been shown to generate a strong antitumor response. Although local …

With the continuous development of immunotherapy, researchers have paid more attention
to the specific immune regulatory mechanisms of various immune responses in different …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

The aberrant appearance of DNA in the cytoplasm triggers the activation of cGAS-cGAMP-
STING signaling and induces the production of type I interferons, which play critical roles in …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors
mutations in homologous recombination–repair (HR-repair) proteins in 20%–25% of cases …