Chemical biology approaches have a long history in the exploration of the G‐protein‐
coupled receptor (GPCR) family, which represents the largest and most important group of …

It has long been recognized that knowledge of the 3D structures of proteins has the potential
to accelerate drug discovery, but recent developments in genome sequencing, robotics and …

The interrogation of single cells has revolutionised biology and medicine by providing
crucial unparalleled insights into cell-to-cell heterogeneity. Flow cytometry (including …

We describe a statistical analysis methodology designed to minimize the impact of off-target
activities upon large-scale RNA interference (RNAi) screens in mammalian cells. Application …

Current-generation angiotensin-converting enzyme (ACE) inhibitors are widely used for
cardiovascular diseases, including high blood pressure, heart failure, heart attack and …

Developing improved methods for CO2 capture and concentration (CCC) is essential to
mitigating the impact of our current emissions and can lead to carbon net negative …

Virtual screening is a much discussed topic in chemoinformatics and medicinal chemistry,
and widely applied in pharmaceutical research. Here, we provide an in-depth analysis of …

Metal–organic frameworks (MOFs) present a combinatorial design challenge. The structural
building blocks of MOFs can be combined to synthesize a nearly infinite number of …

The ever-increasing capability of computational methods has resulted in their general
acceptance as a key part of the materials design process. Traditionally this has been …

Modern chemotherapy has significantly improved patient outcomes against drug-sensitive
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …