The bidirectional gut–lung axis in chronic obstructive pulmonary disease
Epidemiological studies indicate that chronic obstructive pulmonary disease (COPD) is
associated with the incidence of changes in intestinal health. Cigarette smoking, as one of …
associated with the incidence of changes in intestinal health. Cigarette smoking, as one of …
Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models
Skeletal muscle wasting, whether related to physiological ageing, muscle disuse or to an
underlying chronic disease, is a key determinant to quality of life and mortality. However …
underlying chronic disease, is a key determinant to quality of life and mortality. However …
The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi
LLY Chan, DE Anderson, HS Cheng, FX Ivan… - Nature …, 2022 - nature.com
Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation and
infective exacerbations, however, in-vitro model systems for the study of host-pathogen …
infective exacerbations, however, in-vitro model systems for the study of host-pathogen …
Novel anti-inflammatory approaches to COPD
M Cazzola, NA Hanania, CP Page… - International journal of …, 2023 - Taylor & Francis
Airway inflammation, driven by different types of inflammatory cells and mediators, plays a
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …
Recent advances in human respiratory epithelium models for drug discovery
The respiratory epithelium is intimately associated with the pathophysiologies of highly
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …
Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD)
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide, and its global health burden is increasing. COPD is characterized by …
worldwide, and its global health burden is increasing. COPD is characterized by …
Cigarette smoke-induced injury induces distinct sex-specific transcriptional signatures in mice tracheal epithelial cells
B Ghosh, PP Chengala, S Shah… - … of Physiology-Lung …, 2023 - journals.physiology.org
The airway epithelial barrier is crucial for defending against respiratory insults and diseases.
Disruption of epithelial integrity contributes to respiratory diseases, and sex-specific …
Disruption of epithelial integrity contributes to respiratory diseases, and sex-specific …
Respiratory viral infections in exacerbation of chronic airway inflammatory diseases: novel mechanisms and insights from the upper airway epithelium
KS Tan, RL Lim, J Liu, HH Ong, VJ Tan… - Frontiers in cell and …, 2020 - frontiersin.org
Respiratory virus infection is one of the major sources of exacerbation of chronic airway
inflammatory diseases. These exacerbations are associated with high morbidity and even …
inflammatory diseases. These exacerbations are associated with high morbidity and even …
Advanced in vitro lung models for drug and toxicity screening: the promising role of induced pluripotent stem cells
The substantial socioeconomic burden of lung diseases, recently highlighted by the
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model
Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent
micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. IPF is …
micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. IPF is …