[HTML][HTML] Molecular mechanisms and potential new therapeutic drugs for liver fibrosis
FD Wang, J Zhou, EQ Chen - Frontiers in pharmacology, 2022 - frontiersin.org
Liver fibrosis is the pathological process of excessive extracellular matrix deposition after
liver injury and is a precursor to cirrhosis, hepatocellular carcinoma (HCC). It is essentially a …
liver injury and is a precursor to cirrhosis, hepatocellular carcinoma (HCC). It is essentially a …
Mechanistic insight into immunomodulatory effects of food-functioned plant secondary metabolites
Medicinally important plant-foods offer a balanced immune function, which is essential for
protecting the body against antigenic invasion, mainly by microorganisms …
protecting the body against antigenic invasion, mainly by microorganisms …
[HTML][HTML] Quercetin activates vitamin D receptor and ameliorates breast cancer induced hepatic inflammation and fibrosis
NG Sannappa Gowda, VD Shiragannavar… - Frontiers in …, 2023 - frontiersin.org
Aims: To explore the hepatoprotective role of quercetin and its novel molecular mechanism
of action on breast cancer associated hepatic inflammation and fibrosis via Vitamin D …
of action on breast cancer associated hepatic inflammation and fibrosis via Vitamin D …
[HTML][HTML] Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals
Patients with diabetes are at risk for liver disorders including glycogen hepatopathy, non-
alcoholic fatty liver disease, cirrhosis, and hepatic fibrosis. The pathophysiological …
alcoholic fatty liver disease, cirrhosis, and hepatic fibrosis. The pathophysiological …
An in-silico identification of potential flavonoids against kidney fibrosis targeting TGFβR-1
Fibrosis is a hallmark of progressive kidney diseases. The overexpression of profibrotic
cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and …
cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and …
Proanthocyanidins attenuated liver damage and suppressed fibrosis in CCl4-treated rats
MA Amer, AI Othman, MA El-Missiry, AA Farag… - … Science and Pollution …, 2022 - Springer
Liver damage and fibrosis are serious health problems without effective treatment.
Proanthocyanidins (PAs) are flavonoids with several biological effects. We investigated the …
Proanthocyanidins (PAs) are flavonoids with several biological effects. We investigated the …
Suaeda glauca Attenuates Liver Fibrosis in Mice by Inhibiting TGFβ1-Smad2/3 Signaling in Hepatic Stellate Cells
YJ Hong, GH Kim, Y Park, HJ Jo, MW Nam, DG Kim… - Nutrients, 2023 - mdpi.com
Chronic liver injury due to various hepatotoxic stimuli commonly leads to fibrosis, which is a
crucial factor contributing to liver disease-related mortality. Despite the potential benefits of …
crucial factor contributing to liver disease-related mortality. Despite the potential benefits of …
[HTML][HTML] Structural-guided identification of small molecule inhibitor of UHRF1 methyltransferase activity
Ubiquitin-like containing plant homeodomain Ring Finger 1 (UHRF1) protein is recognized
as a cell-cycle-regulated multidomain protein. UHRF1 importantly manifests the …
as a cell-cycle-regulated multidomain protein. UHRF1 importantly manifests the …
[HTML][HTML] Curdione and schisandrin C synergistically reverse hepatic fibrosis via modulating the TGF-β pathway and inhibiting oxidative stress
W Dai, Q Qin, Z Li, L Lin, R Li, Z Fang, Y Han… - Frontiers in cell and …, 2021 - frontiersin.org
Hepatic fibrosis is the final pathway of several chronic liver diseases, which is characterized
by the accumulation of extracellular matrix due to chronic hepatocyte damage. Activation of …
by the accumulation of extracellular matrix due to chronic hepatocyte damage. Activation of …
The preventive and therapeutic potential of the flavonoids in liver cirrhosis: current and future perspectives
R Sahu, S Goswami, G Narahari Sastry… - Chemistry & …, 2023 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) may vary from moderately mild non‐alcohol fatty
liver (NAFL) towards the malignant variant known as non‐alcoholic steatohepatitis (NASH) …
liver (NAFL) towards the malignant variant known as non‐alcoholic steatohepatitis (NASH) …