[HTML][HTML] Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection
Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …
disease. These drugs have not consistently demonstrated high efficacy in preventing or …
[HTML][HTML] Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients …
MR Lewin, RW Carter, IA Matteo, SP Samuel, S Rao… - Toxins, 2022 - mdpi.com
The availability of effective, reliably accessible, and affordable treatments for snakebite
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …
[HTML][HTML] The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
[HTML][HTML] Inflammation and oxidative stress in snakebite envenomation: a brief descriptive review and clinical implications
D Resiere, H Mehdaoui, R Neviere - Toxins, 2022 - mdpi.com
Snakebite envenoming is a pathological condition which may occur in response to the
injection of venom. Snake venoms contain a complex mixture of biologically active …
injection of venom. Snake venoms contain a complex mixture of biologically active …
[HTML][HTML] The BRAVO clinical study protocol: oral varespladib for inhibition of secretory phospholipase A2 in the treatment of snakebite envenoming
RW Carter, CJ Gerardo, SP Samuel, S Kumar… - toxins, 2022 - mdpi.com
Introduction: Snakebite is an urgent, unmet global medical need causing significant
morbidity and mortality worldwide. Varespladib is a potent inhibitor of venom secretory …
morbidity and mortality worldwide. Varespladib is a potent inhibitor of venom secretory …
[HTML][HTML] Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations
AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …
[HTML][HTML] Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology
JS Cavalcante, DEG de Almeida… - International Journal of …, 2023 - mdpi.com
Snakebite envenoming represents a major health problem in tropical and subtropical
countries. Considering the elevated number of accidents and high morbidity and mortality …
countries. Considering the elevated number of accidents and high morbidity and mortality …
[HTML][HTML] Neuromuscular weakness and paralysis produced by snakebite envenoming: mechanisms and proposed standards for clinical assessment
PE Bickler, M Abouyannis, A Bhalla, MR Lewin - Toxins, 2023 - mdpi.com
Respiratory and airway-protective muscle weakness caused by the blockade of
neuromuscular transmission is a major cause of early mortality from snakebite envenoming …
neuromuscular transmission is a major cause of early mortality from snakebite envenoming …
[HTML][HTML] Experimental Bothrops atrox Envenomation: Blood Plasma Proteome Effects after Local Tissue Damage and Perspectives on Thromboinflammation
JS Cavalcante, IMC Brito, LA De Oliveira, LC De Barros… - Toxins, 2022 - mdpi.com
The clinical manifestations of Bothrops atrox envenoming involve local and systemic
changes, among which edema requires substantial attention due to its ability to progress to …
changes, among which edema requires substantial attention due to its ability to progress to …
[PDF][PDF] Venoms classification and therapeutic uses: a narrative review.
The mere glimpse of venomous animals has always terrified humans because of the
devastating effects of their venoms. However, researchers across the globe have isolated …
devastating effects of their venoms. However, researchers across the globe have isolated …