Solid organ transplantation has become an integral part of the management of patients with
end-stage diseases of the kidney, liver, heart and lungs. Most procedures occur in isolation …

Advances in microsystem engineering have enabled the development of highly controlled
models of the liver that better recapitulate the unique in vivo biological conditions. In just a …

Abstract Background and Aims Autosomal dominant polycystic liver and kidney disease is a
spectrum of hereditary diseases, which display disturbed function of primary cilia leading to …

Mouse models of autosomal dominant polycystic kidney disease (ADPKD) show that intact
primary cilia are required for cyst growth following the inactivation of polycystin-1. The …

Requirement of RORα for maintenance and antitumor immunity o... : Hepatology Requirement of
RORα for maintenance and antitumor immunity of liver‐resident natural killer cells/ILC1s …

α-1, 2-mannosyltransferase (ALG9) germline variants are linked to autosomal dominant
polycystic kidney disease (ADPKD). Many individuals affected with ADPKD possess …

Background & Aims Cholangiocytes transit from quiescence to hyperproliferation during
cystogenesis in polycystic liver disease (PLD), the severity of which displays prominent sex …

The progressive formation of single or multiple cysts accompanies several renal diseases.
Specifically,(i) genetic forms, such as adult dominant polycystic kidney disease (ADPKD) …

SEC61A1 encodes a central protein of the mammalian translocon and dysfunction results in
severe disease. Recently, mutation R236C was identified in patients having autosomal …

Protein-truncating variants in α-1, 3-glucosyltransferase (ALG8) are a risk factor for a mild
cystic kidney disease phenotype. The association between these variants and liver cysts is …