Cannabinoids and drug metabolizing enzymes: Potential for drug-drug interactions and implications for drug safety and efficacy

K Bardhi, S Coates, CJW Watson… - Expert Review of Clinical …, 2022 - Taylor & Francis
Introduction Cannabis is an increasingly popular recreational and medicinal drug in the
USA. While cannabis is still a Schedule 1 drug federally, many states have lifted the ban on …

Cannabidiol drug interaction considerations for prescribers and pharmacists

M Graham, JH Martin, CJ Lucas, B Murnion… - Expert Review of …, 2022 - Taylor & Francis
Introduction In light of the widespread use of non-prescribed and prescribed cannabidiol, the
use of cannabidiol with other medications is likely, and this may result in drug interactions …

A physiologically-based pharmacokinetic model for cannabidiol in healthy adults, hepatically-impaired adults, and children

S Bansal, MK Ladumor, MF Paine… - Drug Metabolism and …, 2023 - ASPET
Cannabidiol (CBD) is available as a prescription oral drug that is indicated for the treatment
of some types of epilepsy in children and adults. CBD is also available over-the-counter and …

Verifying in vitro‐determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically‐based pharmacokinetic …

CHT Yeung, JL Beers, KD Jackson… - CPT: Pharmacometrics …, 2023 - Wiley Online Library
Cannabidiol (CBD) is approved for treatment of seizures associated with two forms of
epilepsy that become apparent in infancy or early childhood. To consider an adult …

[HTML][HTML] The influence of cannabidiol on the pharmacokinetics of methylphenidate in healthy subjects

JS Markowitz, L De Faria, Q Zhang… - Medical Cannabis and …, 2022 - karger.com
Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available
as an over-the-counter supplement, a component of medical cannabis, and a prescriptive …

Advances and challenges in modeling cannabidiol pharmacokinetics and hepatotoxicity

JL Beers, Z Zhou, KD Jackson - Drug Metabolism and Disposition, 2024 - ASPET
Cannabidiol (CBD) is a pharmacologically active metabolite of cannabis that is US Food and
Drug Administration approved to treat seizures associated with Lennox-Gastaut syndrome …

CBD and THC in Special Populations: Pharmacokinetics and Drug–Drug Interactions

L Qian, JL Beers, KD Jackson, Z Zhou - Pharmaceutics, 2024 - mdpi.com
Cannabinoid use has surged in the past decade, with a growing interest in expanding
cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) applications into special …

Drug interactions with Cannabis sativa: Mechanisms and clinical implication

A Hasanpoor, M Akaberi, P Kesharwani… - … Analytique et Clinique, 2024 - Elsevier
The therapeutic properties of cannabis have been recognized for thousands of years. The
main active compounds in cannabis that have been scientifically proven to possess …

Involvement of esterases in the pulmonary metabolism of beclomethasone dipropionate and the potential influence of cannabis use

Y Qian, PW Melchert, JS Markowitz - Chemico-Biological Interactions, 2022 - Elsevier
Beclomethasone dipropionate (BDP) is an inhaled glucocorticoid used for maintenance
treatment of asthma in adults and children. BDP is a prodrug activated in lung when …

Pediatric Physiologically Based Pharmacokinetic (PBPK) Modeling to Advance Knowledge of Breastfeeding Infant Exposure to Maternal Medications

CHT Yeung - 2023 - uwspace.uwaterloo.ca
While there are benefits of breastfeeding to the maternal-infant pair, mothers taking
medication may decide not to breastfeed amid unclear risks of exposing the infant to the …