Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence
Y Tan, Z Zhang, C Zheng, KA Wintergerst… - Nature Reviews …, 2020 - nature.com
The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied
in the past decade, but effective approaches to prevent and treat this disease are limited …
in the past decade, but effective approaches to prevent and treat this disease are limited …
PGC‐1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism
S Rius-Pérez, I Torres-Cuevas, I Millán… - Oxidative medicine …, 2020 - Wiley Online Library
Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …
coactivator described as a master regulator of mitochondrial biogenesis and function …
Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity
G Jia, MA Hill, JR Sowers - Circulation research, 2018 - Am Heart Assoc
Heart failure and related morbidity and mortality are increasing at an alarming rate, in large
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …
Endothelial cell metabolism
G Eelen, P de Zeeuw, L Treps, U Harjes… - Physiological …, 2018 - journals.physiology.org
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …
active players in the formation of new blood vessels (angiogenesis) both in health and (life …
Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
BS Karam, A Chavez-Moreno, W Koh, JG Akar… - Cardiovascular …, 2017 - Springer
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several
risk factors promote AF, among which diabetes mellitus has emerged as one of the most …
risk factors promote AF, among which diabetes mellitus has emerged as one of the most …
Molecular and cellular mechanisms of cardiovascular disorders in diabetes
MS Shah, M Brownlee - Circulation research, 2016 - Am Heart Assoc
The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …
Autophagy in the diabetic heart: a potential pharmacotherapeutic target in diabetic cardiomyopathy
S Dewanjee, J Vallamkondu, RS Kalra, A John… - Ageing research …, 2021 - Elsevier
Association of diabetes with an elevated risk of cardiac failure has been clinically evident.
Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction …
Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction …
An overview of murine high fat diet as a model for type 2 diabetes mellitus
A Heydemann - Journal of diabetes research, 2016 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is a worldwide epidemic, which by all predictions will only
increase. To help in combating the devastating array of phenotypes associated with T2DM a …
increase. To help in combating the devastating array of phenotypes associated with T2DM a …
Diabetic cardiomyopathy: current and future therapies. Beyond glycemic control
G Borghetti, D Von Lewinski, DM Eaton… - Frontiers in …, 2018 - frontiersin.org
Diabetes mellitus and the associated complications represent a global burden on human
health and economics. Cardiovascular diseases are the leading cause of death in diabetic …
health and economics. Cardiovascular diseases are the leading cause of death in diabetic …
Modulation of metabolic detoxification pathways using foods and food‐derived components: a scientific review with clinical application
RE Hodges, DM Minich - Journal of nutrition and metabolism, 2015 - Wiley Online Library
Research into human biotransformation and elimination systems continues to evolve.
Various clinical and in vivo studies have been undertaken to evaluate the effects of foods …
Various clinical and in vivo studies have been undertaken to evaluate the effects of foods …