Stress granules are assemblies of untranslating messenger ribonucleoproteins (mRNPs)
that form from mRNAs stalled in translation initiation. Stress granules form through …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

Within cells, soluble RNPs can switch states to coassemble and condense into liquid or solid
bodies. Although these phase transitions have been reconstituted in vitro, for endogenous …

Cellular stress leads to reprogramming of mRNA translation and formation of stress granules
(SGs), membraneless organelles consisting of mRNA and RNA-binding proteins. Although …

Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR)
and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and …

Protein synthesis is one of the most energy consuming processes in the cell. The
mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that …

The accumulation of stalled translation preinitiation complexes (PICs) mediates the
condensation of stress granules (SGs). Interactions between prion-related domains and …

Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize
post-transcriptional control mechanisms to re-program gene expression in ways that …

RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA
composition of EVs is challenging due to their coisolation with contaminants, lack of …

Innate immune responses combat infectious microorganisms by inducing inflammatory
responses, antimicrobial pathways and adaptive immunity. Multiple genes within each of …