Are periaqueductal gray and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review
C Silva, N McNaughton - Progress in neurobiology, 2019 - Elsevier
Many see the periaqueductal gray (PAG) as a region responsible for the downstream control
of defensive reactions. Here we provide a detailed review of anatomical and functional data …
of defensive reactions. Here we provide a detailed review of anatomical and functional data …
The role of descending pain modulation in chronic primary pain: potential application of drugs targeting serotonergic system
ZY Tao, PX Wang, SQ Wei, RJ Traub, JF Li… - Neural …, 2019 - Wiley Online Library
Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …
Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial …
RB Malvestio, P Medeiros, SE Negrini-Ferrari… - Brain Research …, 2021 - Elsevier
The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is a cerebral division that
is putatively implicated in the chronic pain and depression. We investigated the activity of …
is putatively implicated in the chronic pain and depression. We investigated the activity of …
Defensive and emotional behavior modulation by serotonin in the periaqueductal gray
P Vázquez-León, A Miranda-Páez… - Cellular and Molecular …, 2023 - Springer
Abstract Serotonin 5-hydroxytryptamine (5-HT) is a key neurotransmitter for the modulation
and/or regulation of numerous physiological processes and psychiatric disorders (eg …
and/or regulation of numerous physiological processes and psychiatric disorders (eg …
N-methyl-d-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain
P Medeiros, SE Negrini-Ferrari, E Palazzo… - Neurochemical …, 2019 - Springer
The mechanisms underlying chronic and neuropathic pain pathology involve peripheral and
central sensitisation. The medial prefrontal cortex (mPFC) seems to participate in pain …
central sensitisation. The medial prefrontal cortex (mPFC) seems to participate in pain …
GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception …
M Mendonça-dos-Santos, TCT Gonçalves… - Scientific Reports, 2024 - nature.com
We investigated the participation of the nucleus of the tractus solitarius (NTS) in tonic‒clonic
seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS …
seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS …
5-Hydroxytryptamine2A/2C receptors of nucleus raphe magnus and gigantocellularis/paragigantocellularis pars α reticular nuclei modulate the unconditioned fear …
R de Oliveira, RC de Oliveira… - Behavioural Brain …, 2017 - Elsevier
The electrical stimulation of the dorsolateral columns of the periaquedutal grey matter
(dlPAG) or deep layers of the superior colliculus (dlSC) evokes defensive behaviours …
(dlPAG) or deep layers of the superior colliculus (dlSC) evokes defensive behaviours …
The primary motor cortex electrical and chemical stimulation attenuates the chronic neuropathic pain by activation of the periaqueductal grey matter: the role of NMDA …
SE Negrini-Ferrari, P Medeiros, RB Malvestio… - Behavioural Brain …, 2021 - Elsevier
Background Motor cortex stimulation (MCS) is proper as a non-pharmacological therapy for
patients with chronic and neuropathic pain (NP). Aims This work aims to investigate if the …
patients with chronic and neuropathic pain (NP). Aims This work aims to investigate if the …
µ1‐Opioid receptors in the dorsomedial and ventrolateral columns of the periaqueductal grey matter are critical for the enhancement of post‐ictal antinociception
Generalised tonic and tonic–clonic seizures are followed by significant increase in
nociceptive thresholds in both laboratory animals and humans. The endogenous opioid …
nociceptive thresholds in both laboratory animals and humans. The endogenous opioid …
The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial
G Pickering, A Kastler, N Macian, B Pereira… - Drug Design …, 2015 - Taylor & Francis
Background Paracetamol's (APAP) mechanism of action suggests the implication of
supraspinal structures but no neuroimaging study has been performed in humans. Methods …
supraspinal structures but no neuroimaging study has been performed in humans. Methods …