Why cells need iron: a compendium of iron utilisation

MR Teh, AE Armitage, H Drakesmith - Trends in Endocrinology & …, 2024 - cell.com
Iron deficiency is globally prevalent, causing an array of developmental, haematological,
immunological, neurological, and cardiometabolic impairments, and is associated with …

The evolving landscape of polycythemia vera therapies

J Martinez, S Handa, A Skorodinsky… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction The treatment landscape of polycythemia vera (PV) has seen major
advancements within the last decade including approval of ruxolitinib in the second line …

[HTML][HTML] Neutrophil-to-lymphocyte ratio as a prognostic indicator of mortality in Polycythemia Vera: insights from a prospective cohort analysis

T Barbui, A Carobbio, A Ghirardi, F Fenili… - Blood Cancer …, 2024 - nature.com
We analyzed the neutrophil-to-lymphocyte ratio (NLR) in 1508 patients with PV and found
that those with an NLR≥ 5 were generally older, had a longer disease history, and had …

What are the future prospects for polycythemia vera pharmacotherapies for patients with hydroxyurea resistance?

M Metzger, J Mascarenhas - Expert Opinion on Pharmacotherapy, 2024 - Taylor & Francis
Polycythemia vera (PV) is a chronic myeloproliferative neoplasm characterized by
erythrocytosis in the context of a somatic JAK2 mutation and a hypercellular marrow with …

Pharmacokinetics, pharmacodynamics, and tolerability of an aqueous formulation of rusfertide (PTG‐300), a hepcidin mimetic, in healthy volunteers: A double‐blind …

NB Modi, R Shames, JD Lickliter… - European Journal of …, 2024 - Wiley Online Library
Objectives Rusfertide is a potent peptide mimetic of hepcidin being investigated for the
treatment of polycythemia vera. This randomized, placebo‐controlled, double‐blind study …

Polycythemia vera: past, present and future

AB Patel, L Masarova, RA Mesa, G Hobbs… - Leukemia & …, 2024 - Taylor & Francis
There has been remarkable progress in the development of novel therapeutic approaches
for patients with polycythemia vera (PV). Historically, therapy goals in PV were to mitigate …

Hematocrit control and thrombotic risk in patients with polycythemia vera treated with ruxolitinib in clinical practice

A Chojecki, D Boselli, A Dortilus, I Hamadeh… - Annals of …, 2024 - Springer
Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by unregulated red
blood cell production resulting in elevated hemoglobin and/or hematocrit levels. Patients …

Contemporary Challenges in Polycythemia Vera Management from the Perspective of Patients and Physicians

AT Kuykendall, JT Fine, M Kremyanskaya - Clinical Lymphoma Myeloma …, 2024 - Elsevier
Although polycythemia vera (PV) is a chronic and incurable disease, effective management
can allow most patients to maintain functional lives with near-normal life expectancy …

[HTML][HTML] Hepcidin Mimetic Rusfertide Nearly Eliminates Need for Phlebotomies in PV

L Lawrence - 2024 - ashpublications.org
Treatment with rusfertide, an injectable peptide mimetic of the master iron regulatory
hormone hepcidin, essentially eliminated the need for therapeutic phlebotomies in patients …

Ein Hepcidin-Mimetikum zur Kontrolle der Erythrozytose

E Hiller - InFo Hämatologie+ Onkologie, 2024 - Springer
Hintergrund und Fragestellung: Die Polycythemia vera (PV) ist eine chronische
myeloproliferative Erkrankung, bei der es charakteristischerweise zur Erythrozytose und …