Advances in mRNA vaccines for infectious diseases
C Zhang, G Maruggi, H Shan, J Li - Frontiers in immunology, 2019 - frontiersin.org
During the last two decades, there has been broad interest in RNA-based technologies for
the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have …
the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have …
Codon bias as a means to fine-tune gene expression
The redundancy of the genetic code implies that most amino acids are encoded by multiple
synonymous codons. In all domains of life, a biased frequency of synonymous codons is …
synonymous codons. In all domains of life, a biased frequency of synonymous codons is …
Synonymous mutations in representative yeast genes are mostly strongly non-neutral
Synonymous mutations in protein-coding genes do not alter protein sequences and are thus
generally presumed to be neutral or nearly neutral,,,–. Here, to experimentally verify this …
generally presumed to be neutral or nearly neutral,,,–. Here, to experimentally verify this …
BRAKER3: Fully automated genome annotation using RNA-seq and protein evidence with GeneMark-ETP, AUGUSTUS, and TSEBRA
Gene prediction has remained an active area of bioinformatics research for a long time. Still,
gene prediction in large eukaryotic genomes presents a challenge that must be addressed …
gene prediction in large eukaryotic genomes presents a challenge that must be addressed …
KaKs_Calculator 3.0: calculating selective pressure on coding and non-coding sequences
Z Zhang - Genomics, Proteomics and Bioinformatics, 2022 - academic.oup.com
Abstract KaKs_Calculator 3.0 is an updated toolkit that is capable of calculating selective
pressure on both coding and non-coding sequences. Similar to the nonsynonymous …
pressure on both coding and non-coding sequences. Similar to the nonsynonymous …
Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure
Understanding the genetic regulatory code governing gene expression is an important
challenge in molecular biology. However, how individual coding and non-coding regions of …
challenge in molecular biology. However, how individual coding and non-coding regions of …
Synonymous but not silent: the codon usage code for gene expression and protein folding
Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …
Although synonymous mutations were previously thought to be silent, a large body of …
Codon usage influences the local rate of translation elongation to regulate co-translational protein folding
Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and has
been proposed to regulate translation efficiency, accuracy, and protein folding based on the …
been proposed to regulate translation efficiency, accuracy, and protein folding based on the …
Codon usage is an important determinant of gene expression levels largely through its effects on transcription
Codon usage biases are found in all eukaryotic and prokaryotic genomes, and preferred
codons are more frequently used in highly expressed genes. The effects of codon usage on …
codons are more frequently used in highly expressed genes. The effects of codon usage on …
The distribution of bacterial doubling times in the wild
Generation time varies widely across organisms and is an important factor in the life cycle,
life history and evolution of organisms. Although the doubling time (DT) has been estimated …
life history and evolution of organisms. Although the doubling time (DT) has been estimated …