Primary sclerosing cholangitis
GM Hirschfield, TH Karlsen, KD Lindor, DH Adams - The Lancet, 2013 - thelancet.com
Primary sclerosing cholangitis is the classic hepatobiliary manifestation of inflammatory
bowel disease and is generally chronic and progressive. Patients frequently present with …
bowel disease and is generally chronic and progressive. Patients frequently present with …
Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management
Primary sclerosing cholangitis (PSC), first described in the mid-1850s, is a complex liver
disease that is heterogeneous in its presentation. PSC is characterized by chronic …
disease that is heterogeneous in its presentation. PSC is characterized by chronic …
AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …
[HTML][HTML] Recent advances in the development of farnesoid X receptor agonists
AH Ali, EJ Carey, KD Lindor - Annals of translational medicine, 2015 - ncbi.nlm.nih.gov
Farnesoid X receptors (FXRs) are nuclear hormone receptors expressed in high amounts in
body tissues that participate in bilirubin metabolism including the liver, intestines, and …
body tissues that participate in bilirubin metabolism including the liver, intestines, and …
[HTML][HTML] Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: a multicenter, randomized, double-blind, placebo-controlled phase II trial
GM Hirschfield, O Chazouillères, JP Drenth… - Journal of …, 2019 - Elsevier
Background & Aims Primary sclerosing cholangitis (PSC) is an inflammatory, cholestatic and
progressively fibrotic liver disease devoid of effective medical intervention. NGM282, an …
progressively fibrotic liver disease devoid of effective medical intervention. NGM282, an …
Bile acids in physiology, pathology and pharmacology
Bile acids, synthesized by hepatocytes from cholesterol, are specific and quantitatively
important organic components of bile, where they are the main driving force of the osmotic …
important organic components of bile, where they are the main driving force of the osmotic …
Improvement of serum alkaline phosphatase to< 1.5 upper limit of normal predicts better outcome and reduced risk of cholangiocarcinoma in primary sclerosing …
S Al Mamari, J Djordjevic, JS Halliday… - Journal of hepatology, 2013 - Elsevier
BACKGROUND & AIMS: Normalization of serum alkaline phosphatase (SAP) was recently
shown to correlate with better prognosis in Primary Sclerosing Cholangitis (PSC). We aimed …
shown to correlate with better prognosis in Primary Sclerosing Cholangitis (PSC). We aimed …
[HTML][HTML] Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities
M Vesterhus, TH Karlsen - Journal of gastroenterology, 2020 - Springer
Primary sclerosing cholangitis (PSC) is a progressive liver disease, histologically
characterized by inflammation and fibrosis of the bile ducts, and clinically leading to multi …
characterized by inflammation and fibrosis of the bile ducts, and clinically leading to multi …
Gastrointestinal manifestations of cystic fibrosis
Gastrointestinal symptoms of cystic fibrosis are the most important non-pulmonary
manifestations of this genetic illness. Pancreatic manifestations include acute and chronic …
manifestations of this genetic illness. Pancreatic manifestations include acute and chronic …
Vedolizumab in patients with concurrent primary sclerosing cholangitis and inflammatory bowel disease does not improve liver biochemistry but is safe and effective …
Background Blocking of lymphocyte trafficking to bile ducts is a potential mechanism to alter
the disease course of patients with primary sclerosing cholangitis (PSC). Aim To describe …
the disease course of patients with primary sclerosing cholangitis (PSC). Aim To describe …