In vitro mechanical characterization and modeling of subcutaneous adipose tissue: A comprehensive review

Z Sun, BD Gepner, PS Cottler… - Journal of …, 2021 - asmedigitalcollection.asme.org
Mechanical models of adipose tissue are important for various medical applications
including cosmetics, injuries, implantable drug delivery systems, plastic surgeries …

Using poro-elasticity to model the large deformation of tissue during subcutaneous injection

Y Leng, M de Lucio, H Gomez - Computer Methods in Applied Mechanics …, 2021 - Elsevier
Subcutaneous injection of therapeutic monoclonal antibodies (mAbs) has recently attracted
unprecedented interests in the pharmaceutical industry. The drug transport in the tissue and …

Subcutaneous Drug Delivery: A Review of the State-of-the-Art Modeling and Experimental Techniques

P Sharma, K Gajula, NN Dingari… - Journal of …, 2023 - asmedigitalcollection.asme.org
Delivery of drug formulations through the subcutaneous route is a widely used modality for
the treatment of several diseases, such as diabetes and auto-immune conditions …

Multidirectional mechanical properties and constitutive modeling of human adipose tissue under dynamic loading

Z Sun, BD Gepner, SH Lee, J Rigby, PS Cottler… - Acta Biomaterialia, 2021 - Elsevier
The mechanical behavior of subcutaneous adipose tissue (SAT) affects the interaction
between vehicle occupants and restraint systems in motor vehicle crashes (MVCs). To …

The effects of gravity and compression on interstitial fluid transport in the lower limb

JW Baish, TP Padera, LL Munn - Scientific Reports, 2022 - nature.com
Edema in the limbs can arise from pathologies such as elevated capillary pressures due to
failure of venous valves, elevated capillary permeability from local inflammation, and …

Comparison of porcine and human adipose tissue loading responses under dynamic compression and shear: A pilot study

Z Sun, SH Lee, BD Gepner, J Rigby, JJ Hallman… - Journal of the …, 2021 - Elsevier
Understanding the mechanical properties of human adipose tissue, and its influence on seat
belt-pelvis interaction is beneficial for computational human body models that are developed …

[HTML][HTML] Strain-dependent shear properties of human adipose tissue in vivo

A Hatt, R Lloyd, B Bolsterlee, LE Bilston - Journal of the Mechanical …, 2023 - Elsevier
Introduction Human adipose tissue (fat) deforms substantially under normal physiological
loading and during impact. Thus, accurate data on strain-dependent stiffness of fat is …

A poro-viscoelastic model for the subcutaneous injection of monoclonal antibodies

Y Leng, AM Ardekani, H Gomez - Journal of the Mechanics and Physics of …, 2021 - Elsevier
Subcutaneous delivery of therapeutic monoclonal antibodies (mAbs) has recently attracted
exceptional interests in the pharmaceutical industry. The mechanical response of the tissue …

Theoretical investigation on the thermo-mechanical responses of the human skin during thermal therapy

J Ma, X Yang, Y Sun, J Yang - International Journal of Mechanical Sciences, 2019 - Elsevier
Laser ablation is an efficient technique of thermal treatment for tumor, during which process,
temperature of the tumor tissue will be elevated by the laser beam. Irreversible burn and …

Mechanical characterisation of commercial artificial skin models

ASK Kho, S Béguin, ED O'Cearbhaill… - Journal of the Mechanical …, 2023 - Elsevier
Understanding of the mechanical properties of skin is crucial in evaluating the performance
of skin-interfacing medical devices. Artificial skin models (ASMs) have rapidly gained …