Traumatic brain injury: progress and challenges in prevention, clinical care, and research
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …
neurological disorders, and poses a substantial public health burden. TBI is increasingly …
Blood GFAP as an emerging biomarker in brain and spinal cord disorders
Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of …
introduction of highly sensitive immunoassays led to a rapid increase in the number of …
Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury
Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …
Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues
Background The use of blood biomarkers after mild traumatic brain injury (mTBI) has been
widely studied. We have identified eight unresolved issues related to the use of five …
widely studied. We have identified eight unresolved issues related to the use of five …
Serum metabolome associated with severity of acute traumatic brain injury
Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain
injury (TBI). Associations between this and systemic metabolism and their potential …
injury (TBI). Associations between this and systemic metabolism and their potential …
Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study
Background Several studies have reported an association between serum biomarker values
and functional outcome following traumatic brain injury. We aimed to examine the …
and functional outcome following traumatic brain injury. We aimed to examine the …
Post-acute blood biomarkers and disease progression in traumatic brain injury
There is substantial interest in the potential for traumatic brain injury to result in progressive
neurological deterioration. While blood biomarkers such as glial fibrillary acid protein …
neurological deterioration. While blood biomarkers such as glial fibrillary acid protein …
The association between inflammatory markers in blood and cerebrospinal fluid: a systematic review and meta-analysis
FAJ Gigase, E Smith, B Collins, K Moore… - Molecular …, 2023 - nature.com
Background Neuroinflammatory processes have been hypothesized to play a role in the
pathogenesis of psychiatric and neurological diseases. Studies on this topic often rely on …
pathogenesis of psychiatric and neurological diseases. Studies on this topic often rely on …
Unique diagnostic signatures of concussion in the saliva of male athletes: the Study of Concussion in Rugby Union through MicroRNAs (SCRUM)
V Di Pietro, P O'Halloran, CN Watson… - British journal of sports …, 2021 - bjsm.bmj.com
Objective To investigate the role of salivary small non-coding RNAs (sncRNAs) in the
diagnosis of sport-related concussion. Methods Saliva was obtained from male professional …
diagnosis of sport-related concussion. Methods Saliva was obtained from male professional …
The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury
Abstract HUIBREGTSE, ME, Bazarian, JJ, Shultz, SR, and Kawata K. The biological
significance and clinical utility of emerging blood biomarkers for traumatic brain injury …
significance and clinical utility of emerging blood biomarkers for traumatic brain injury …