Anti-hepatocellular carcinoma biomolecules: molecular targets insights

N Juaid, A Amin, A Abdalla, K Reese, Z Alamri… - International journal of …, 2021 - mdpi.com
This report explores the available curative molecules directed against hepatocellular
carcinoma (HCC). Limited efficiency as well as other drawbacks of existing molecules led to …

[HTML][HTML] An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin

S Bastani, V Vahedian, M Rashidi, A Mir… - Biomedicine & …, 2022 - Elsevier
Crocin, an active ingredient derived from saffron, is one of the herbal components that has
recently been considered by researchers. Crocin has been shown to have many anti …

Effects of sorafenib and quercetin alone or in combination in treating hepatocellular carcinoma: in vitro and in vivo approaches

S Abdu, N Juaid, A Amin, M Moulay, N Miled - Molecules, 2022 - mdpi.com
Sorafenib is the first drug approved to treat advanced hepatocellular carcinoma (HCC) and
continues as the gold-standard therapy against HCC. However, acquired drug resistance …

Saffron and its major ingredients' effect on colon cancer cells with mismatch repair deficiency and microsatellite instability

A Amin, A Farrukh, C Murali, A Soleimani, F Praz… - Molecules, 2021 - mdpi.com
Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. One
of its subtypes is associated with defective mismatch repair (dMMR) genes. Saffron has …

[HTML][HTML] Safranal prevents liver cancer through inhibiting oxidative stress and alleviating inflammation

Y Abdalla, A Abdalla, AA Hamza, A Amin - Frontiers in Pharmacology, 2022 - frontiersin.org
Despite all efforts, an effective and safe treatment for liver cancer remains elusive. Natural
products and their derived biomolecules are potential resources to mine for novel anti …

[HTML][HTML] Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review

M Zeinali, MR Zirak, SA Rezaee, G Karimi… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
The medicinal uses of saffron, the dried stigmas of Crocus sativus L., have very long history
in food coloring agent, and flavoring agent as well as traditional medicine for the treatment of …

Aescin and diosmin each alone or in low dose-combination ameliorate liver damage induced by carbon tetrachloride in rats

SM El-Dakhly, AAA Salama, SOM Hassanin… - BMC Research …, 2020 - Springer
Objective This study evaluated hepatoprotective effect of aescin (AES) and diosmin (DIO),
individually or in low-dose combination in chemically induced liver injury in rats. Rats were …

Crocin: A fighter against inflammation and pain

M Hashemzaei, C Mamoulakis, K Tsarouhas… - Food and Chemical …, 2020 - Elsevier
Crocin, a water-soluble carotenoid, is known as a pharmacologically active compound,
particularly for its potent anti-oxidant activity. The present work provides a comprehensive …

Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and …

RM De Pablos, AM Espinosa-Oliva… - Pharmacological …, 2019 - Elsevier
Aging is a complex process. It is considered a risk factor for several diseases such as
cancer, neurodegenerative diseases, cardiovascular diseases, and diabetes, most of which …

Saffron: the golden spice with therapeutic properties on digestive diseases

H Ashktorab, A Soleimani, G Singh, A Amin… - Nutrients, 2019 - mdpi.com
Saffron is a natural compound that has been used for centuries in many parts of the world as
a food colorant and additive. It was shown to have the ability to mitigate various disorders …