Alzheimer's disease (AD) is characterized by a chronic and progressive neurodegenerative
process resulting from the intracellular and extracellular accumulation of fibrillary proteins …

The neuromuscular junction (NMJ) is a peripheral synaptic connection between presynaptic
motor neurons and postsynaptic skeletal muscle fibers that enables muscle contraction and …

Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease involving loss
of motor neurons (MNs) and muscle atrophy, still has no effective treatment, despite much …

Neuronal activity in the brain reflects an excitation–inhibition balance that is regulated
predominantly by glutamatergic and GABAergic neurotransmission, and often disturbed in …

Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …

Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

Excitatory amino acid transporters (EAATs) encompass a class of five transporters with
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …

Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …

Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in
excess of those of other amino acids. In glutamate-containing vesicles in the brain, the …

Dysfunction of microRNA (miRNA) metabolism is thought to underlie diseases affecting
motoneurons. One miRNA, miR-218, is abundantly and selectively expressed by developing …