Neurodegenerative disease is a kind of chronic, progressive nervous system disease
characterized by neuron degeneration or apoptosis. Current treatments cannot prevent the …

Life expectancy of humans has increased continuously up to the present days, but their
health status (healthspan) was not enhanced by similar extent. To decrease enormous …

Recently, we provided genetic basis showing that mitochondrial dysfunction can trigger
motor neuron degeneration, through identification of CHCHD10 encoding a mitochondrial …

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is an incurable
neurodegenerative condition, characterized by the loss of upper and lower motor neurons. It …

Neuromuscular junction assembly and plasticity during embryonic, postnatal, and adult life
are tightly regulated by the continuous cross-talk among motor nerve endings, muscle fibers …

Frontotemporal dementia (FTD) is a heterogenous neurodegenerative disorder,
characterized by diverse clinical presentations, neuropathological characteristics and …

Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous disease with no effective
treatment. Drug development has been hampered by the lack of biomarkers that aid in early …

We report a method to generate a 3D motor neuron model with segregated and directed
axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a …

The blood–brain barrier (BBB) is a highly specialized and dynamic compartment which
regulates the uptake of molecules and solutes from the blood. The relevance of the …

Alzheimer disease is a multifactorial pathology and the development of new multitarget
neuroprotective drugs is promising and attractive. We synthesized a group of original …