Frequency and risk factor analysis of cognitive and anxiety-depressive disorders in patients with amyotrophic lateral sclerosis/motor neuron disease
F Cui, W Zhu, Z Zhou, Y Ren, Y Li, M Li… - Neuropsychiatric …, 2015 - Taylor & Francis
Objectives To examine the frequency and risk factors of cognitive and anxiety-depressive
disorders in patients with amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) …
disorders in patients with amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) …
New Adamantane-containing Edaravone conjugates as potential neuroprotective agents for ALS treatments
MA Lapshina, EF Shevtsova, VV Grigoriev… - Molecules, 2023 - mdpi.com
Currently, there are no effective drugs for the treatment of amyotrophic lateral sclerosis
(ALS). Only two drugs—edaravone and riluzole—have been approved, but they have very …
(ALS). Only two drugs—edaravone and riluzole—have been approved, but they have very …
Mutant SOD1 prevents normal functional recovery through enhanced glial activation and loss of motor neuron innervation after peripheral nerve injury
S Schram, D Chuang, G Schmidt, H Piponov… - Neurobiology of …, 2019 - Elsevier
Background Amyotrophic lateral sclerosis (ALS) is poorly understood with no effective
therapeutics. One long entertained observation is that ALS may be precipitated focally by …
therapeutics. One long entertained observation is that ALS may be precipitated focally by …
Functional microglia neurotransmitters in amyotrophic lateral sclerosis
Today neuroscience is dominated by the perspective that microglia are essential elements
in any integrated view of the nervous system. A number of different neuroinflammatory …
in any integrated view of the nervous system. A number of different neuroinflammatory …
Combined Treatment with Bojungikgi-Tang and Riluzole Regulates Muscle Metabolism and Dysfunction in the hSOD1G93A Mouse Model
M Cai, EJ Yang - Antioxidants, 2022 - mdpi.com
The progressive neurodegenerative disease, amyotrophic lateral sclerosis (ALS), is
characterized by muscle weakness and atrophy owing to selective motoneuron …
characterized by muscle weakness and atrophy owing to selective motoneuron …
In vitro models of neuromuscular junctions and their potential for novel drug discovery and development
ABSTRACT Introduction: Neuromuscular Junctions (NMJs) are the synapses between motor
neurons and skeletal muscle fibers, and they are responsible for voluntary motor function …
neurons and skeletal muscle fibers, and they are responsible for voluntary motor function …
Unraveling gene expression profiles in peripheral motor nerve from amyotrophic lateral sclerosis patients: insights into pathogenesis
N Riva, F Clarelli, T Domi, F Cerri, F Gallia… - Scientific reports, 2016 - nature.com
The aim of the present study is to investigate the molecular pathways underlying
amyotrophic lateral sclerosis (ALS) pathogenesis within the peripheral nervous system. We …
amyotrophic lateral sclerosis (ALS) pathogenesis within the peripheral nervous system. We …
Rofecoxib attenuates the pathogenesis of amyotrophic lateral sclerosis by alleviating Cyclooxygenase-2-mediated mechanisms
YH Zou, PP Guan, SQ Zhang, YS Guo… - Frontiers in …, 2020 - frontiersin.org
Cyclooxygenase-2 (COX-2) is reported to be activated during the course of amyotrophic
lateral sclerosis (ALS) development and progression. However, the roles of COX-2 in …
lateral sclerosis (ALS) development and progression. However, the roles of COX-2 in …
[HTML][HTML] Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy
MF Hammer, CT Krzyzaniak, E Bahramnejad… - Clinical …, 2024 - portlandpress.com
Background: Epilepsy is a common neurological disease; however, few if any of the
currently marketed antiseizure medications prevent or cure epilepsy. Discovery of …
currently marketed antiseizure medications prevent or cure epilepsy. Discovery of …
Slower progression of amyotrophic lateral sclerosis with external application of a Chinese herbal plaster–The randomized, placebo-controlled triple-blinded ALS …
S Schröder, M Wang, D Sima, J Schröder, X Zhu… - Frontiers in …, 2022 - frontiersin.org
Background Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease
characterized by gradually increasing damage to the upper and lower motor neurons …
characterized by gradually increasing damage to the upper and lower motor neurons …