Immune-checkpoint inhibitors: long-term implications of toxicity
The development of immune-checkpoint inhibitors (ICIs) has heralded a new era in cancer
treatment, enabling the possibility of long-term survival in patients with metastatic disease …
treatment, enabling the possibility of long-term survival in patients with metastatic disease …
Mechanisms driving the immunoregulatory function of cancer cells
A van Weverwijk, KE de Visser - Nature Reviews Cancer, 2023 - nature.com
Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …
activation state of immune cells, which impacts their progression and response to …
Polysaccharide nanodonuts for photochemotherapy‐amplified immunogenic cell death to potentiate systemic antitumor immunity against hepatocellular carcinoma
Y Wang, J Qian, W Xu, J Wang, Z Li… - Advanced Functional …, 2023 - Wiley Online Library
Immunotherapy shows great promise in the treatment of hepatocellular carcinoma (HCC),
however, the low response rate of HCC patients to immunotherapy caused by inadequately …
however, the low response rate of HCC patients to immunotherapy caused by inadequately …
Intestinal microbiota influence doxorubicin responsiveness in triple-negative breast cancer
Simple Summary Triple-negative breast cancer (TNBC) is a highly aggressive tumor with a
poor prognosis and limited treatment options. Finding new approaches to improve TNBC …
poor prognosis and limited treatment options. Finding new approaches to improve TNBC …
Lifestyle and host determinants of antitumor immunity and cancer health disparities
Lifestyle factors exert profound effects on host physiology and immunology. Disparities in
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …
[HTML][HTML] Immunoregulation in cancer-associated cachexia
Background Cancer-associated cachexia is a multi-organ disorder associated with
progressive weight loss due to a variable combination of anorexia, systemic inflammation …
progressive weight loss due to a variable combination of anorexia, systemic inflammation …
The role of obesity and bariatric surgery-induced weight loss in breast cancer
Obesity is a complex metabolic condition considered a worldwide public health crisis, and a
deeper mechanistic understanding of obesity-associated diseases is urgently needed …
deeper mechanistic understanding of obesity-associated diseases is urgently needed …
Metabolic implications of immune checkpoint proteins in cancer
ER Stirling, SM Bronson, JD Mackert, KL Cook… - Cells, 2022 - mdpi.com
Expression of immune checkpoint proteins restrict immunosurveillance in the tumor
microenvironment; thus, FDA-approved checkpoint inhibitor drugs, specifically PD-1/PD-L1 …
microenvironment; thus, FDA-approved checkpoint inhibitor drugs, specifically PD-1/PD-L1 …
Immuno-reactive cancer organoid model to assess effects of the microbiome on cancer immunotherapy
E Shelkey, D Oommen, ER Stirling, DR Soto-Pantoja… - Scientific reports, 2022 - nature.com
Immune checkpoint blockade (ICB) therapy has demonstrated good efficacy in many cancer
types. In cancers such as non-resectable advanced or metastatic triple-negative breast …
types. In cancers such as non-resectable advanced or metastatic triple-negative breast …
Obesity alters immunopathology in cancers and inflammatory diseases
X Zhang, L Gao, H Meng, A Zhang, Y Liang… - Obesity …, 2023 - Wiley Online Library
Obesity is characterized by chronic low‐grade inflammation and is strongly associated with
multiple immunological diseases, including cancer and inflammatory diseases. Recent …
multiple immunological diseases, including cancer and inflammatory diseases. Recent …