Bacterial lineages acquire novel traits at diverse rates in part because the genetic
background impacts the successful acquisition of novel genes by horizontal transfer. Yet …

Klebsiella pneumoniae is a pathogen known for its high frequency of antimicrobial
resistance. Responses to various environmental stresses during its life can influence the …

Background Over the decades, new antibacterial agents have been developed in an attempt
to combat drug resistance, but they remain unsuccessful. Recently, a novel class of bacterial …

One key concept in the evolution of new functions is the ability of enzymes to perform
promiscuous side-reactions that serve as a source of novelty that may become beneficial …

While Extended-Spectrum β-Lactamases (ESBL) and AmpC β-lactamases barely degrade
carbapenem antibiotics, they are able to bind carbapenems and prevent them from …

Carbapenem resistance is mainly mediated by carbapenemases or extended-spectrum β-
lactamases (ESBL) plus a loss of porins. However, we have identified a Klebsiella …

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an urgent threat to human health.
Major outer membrane proteins (OMPs) porin mutation is one important resistance …

Here, we investigated general porin regulation in Yersinia pseudotuberculosis 488, the
causative agent of Far Eastern scarlet-like fever, in response to sublethal concentrations of …

Microbes inhabit natural environments that are remarkably dynamic, with sudden
environmental shifts that require immediate action by the cell. To cope with changing …

Adaptive laboratory evolution is an important tool to evolve organisms to increased
tolerance towards different physical and chemical stress. It is applied to study the evolution …