[HTML][HTML] Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine

Y Matsuzaka, R Yashiro - International Journal of Molecular Sciences, 2022 - mdpi.com
Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in
intracellular communication through EV-encapsulated informative content, including …

Cellular aging secretes: a comparison of bone-marrow-derived and induced mesenchymal stem cells and their secretome over long-term culture

A Marote, D Santos, B Mendes-Pinheiro… - Stem Cell Reviews and …, 2023 - Springer
Mesenchymal stem cells (MSCs) hold promising therapeutic potential in several clinical
applications, mainly due to their paracrine activity. The implementation of future secretome …

[HTML][HTML] Adipose-derived stem cells (ADSCs) supplemented with hepatocyte growth factor (HGF) attenuate hepatic stellate cell activation and liver fibrosis by inhibiting …

S Gharbia, SR Nazarie, S Dinescu, C Balta, H Herman… - Cells, 2022 - mdpi.com
Liver fibrosis can develop on the background of hyperglycemia in diabetes mellitus.
However, xenobiotic-related factors may accelerate diabetes-associated liver fibrosis. In this …

[HTML][HTML] The potential clinical use of stem/progenitor cells and organoids in liver diseases

C Nikokiraki, A Psaraki, MG Roubelakis - Cells, 2022 - mdpi.com
The liver represents the most important metabolic organ of the human body. It is evident that
an imbalance of liver function can lead to several pathological conditions, known as liver …

[HTML][HTML] Effect of hepatic pathology on liver regeneration: the main metabolic mechanisms causing impaired hepatic regeneration

S Rodimova, A Mozherov, V Elagin, M Karabut… - International Journal of …, 2023 - mdpi.com
Liver regeneration has been studied for many decades, and the mechanisms underlying
regeneration of normal liver following resection are well described. However, no less …

[HTML][HTML] Strategies to improve the therapeutic efficacy of mesenchymal stem cell‐derived extracellular vesicle (MSC-EV): a promising cell-free therapy for liver disease

L Zheng, H Gong, J Zhang, L Guo, Z Zhai… - … in Bioengineering and …, 2023 - frontiersin.org
Liver disease has emerged as a significant worldwide health challenge due to its diverse
causative factors and therapeutic complexities. The majority of liver diseases ultimately …

[HTML][HTML] Silk proteinsenriched nanocomposite hydrogels based on modified MMT clay and poly (2-hydroxyethyl methacrylate-co-2-acrylamido-2-methylpropane …

MV Șerban, SR Nazarie, S Dinescu, IC Radu… - Nanomaterials, 2022 - mdpi.com
Due to their remarkable structures and properties, three-dimensional hydrogels and
nanostructured clay particles have been extensively studied and have shown a high …

Mechanisms of Action of Mesenchymal Stem Cells in Metabolic‐Associated Fatty Liver Disease

S Yi, Q Cong, Y Zhu, Q Xu - Stem Cells International, 2023 - Wiley Online Library
Metabolic‐associated fatty liver disease (MAFLD) is currently the most common chronic liver
disease worldwide. However, its pathophysiological mechanism is complicated, and …

[HTML][HTML] Tackling the effects of extracellular vesicles in fibrosis

M Martín-Taboada, P Corrales… - European Journal of …, 2022 - Elsevier
Fibrosis is a physiological process of tissue repair that turns into pathological when
becomes chronic, damaging the functional structure of the tissue. In this review we outline …

Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications

L Li, S Hua, L You, T Zhong - Current Stem Cell Research & …, 2024 - benthamdirect.com
Diabetes is a complex metabolic disease with a high global prevalence. The health and
quality of life of patients with diabetes are threatened by many complications, including …