The most important discoveries in pharmacology, such as certain classes of analgesics or
chemotherapeutics, started from natural extracts which have been found to have effects in …

Chronic neuropathic pain is a debilitating pain syndrome caused by damage to the nervous
system that is poorly served by current medications. Given these problems, clinical studies …

The anxiolytic and antidepressant properties of cannabidiol (CBD) have been evaluated in
several studies. However, the molecular mechanisms involved in these actions remain …

Depression is characterized by continuous low mood and loss of interest or pleasure in
enjoyable activities. First-line medications for mood disorders mostly target the …

Cannabidiol (CBD) is one of the most interesting constituents of cannabis, garnering
significant attention in the medical community in recent years due to its proven benefit for …

The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian
physiology. ECS has gained substantial interest since growing evidence suggests that it …

This study aimed to determine if orally administered cannabidiol (CBD) lessens the cortical
over-release of glutamate induced by a severe traumatic brain injury (TBI) and facilitates …

Understanding the neurobiological underpinnings of depressive disorder constitutes a
pressing challenge in the fields of psychiatry and neurobiology. Depression represents one …

Background Motor cortex stimulation (MCS) is proper as a non-pharmacological therapy for
patients with chronic and neuropathic pain (NP). Aims This work aims to investigate if the …

Depression has a high rate of comorbidity with neuropathic pain. This study aims to
investigate the effect of Mygalin, an acylpolyamine synthesized from a natural molecule in …