Introduction: Genome editing using CRISPR/Cas9 has advanced very rapidly in its scope,
versatility and ease of use. Zebrafish (Danio rerio) has been one of the vertebrate model …

Glycine mediates fast inhibitory synaptic transmission. Physiological importance of the
glycinergic synapse is well established in the brainstem and the spinal cord. In humans, the …

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), such as eicosapentaenoic acid (20: 5n-3,
EPA) and docosahexaenoic acid (22: 6n-3, DHA), are essential for neural development and …

The musculoskeletal system is a striking example of how cell identity and position is
coordinated across multiple tissues to ensure function. However, it is unclear upon tissue …

We recently introduced the Cre/Lox technology in our laboratory for both transient (mRNA
injections) and stable/transgenic experiments. We experienced significant issues such as …

Oligodendrocytes form myelin around axons of the central nervous system, enabling
saltatory conduction. Recent work has established that axons can regulate certain aspects of …

Deciphering the connectome, the ensemble of synaptic connections that underlie brain
function, is a central goal of neuroscience research. The trans-Tango genetic approach …

Methods to label cell populations selectively or to modify their gene expression are critical
tools in the study of developmental or physiological processes in vivo. A variety of …

Advanced technologies for toxicity tests are designed to identify biomarkers with superior
predictive power or end points of the complex web of biological pathways. However, the …

The current therapies for treating tumors are lacking in efficacy and specificity. Synthetic
biology principles may bring some new possible methods for curing cancer. Here we …