Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery

M Ashrafizadeh, A Zarrabi, S Mirzaei, F Hashemi… - Food and Chemical …, 2021 - Elsevier
Cancer is the second leading cause of death worldwide. Majority of recent research efforts in
the field aim to address why cancer resistance to therapy develops and how to overcome or …

[HTML][HTML] Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney …

SE Owumi, AI Kazeem, B Wu, LO Ishokare… - Scientific Reports, 2022 - nature.com
Sorghum bicolor plant has a high abundance of 3-deoxyanthocyanins, flavonoids and other
polyphenol compounds that have been shown to offer numerous health benefits …

Counteracting effects of heavy metals and antioxidants on male fertility

S Ghafouri-Fard, H Shoorei, M Mohaqiq, M Tahmasebi… - Biometals, 2021 - Springer
Infertility is regarded as a global health problem affecting 8–12% of couples. Male factors
are regarded as the main cause of infertility in 40% of infertile couples and contribute to this …

Caffeic acid mitigates aflatoxin B1‐mediated toxicity in the male rat reproductive system by modulating inflammatory and apoptotic responses, testicular function, and …

SE Owumi, CE Irozuru, UO Arunsi… - Journal of food …, 2022 - Wiley Online Library
Abstract Aflatoxin B1 (AFB1) is a toxic metabolite of public health concern. The present study
investigates the protective effects of caffeic acid (CA) against AFB1‐induced oxidative stress …

Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment

SE Owumi, SO Nwozo, UO Arunsi, AK Oyelere… - Toxicology and applied …, 2021 - Elsevier
Doxorubicin (DOX), is a drug against lung malignancies with undesirable side effect
including oxidative, inflammatory and apoptotic effects. Luteolin (LUT), present in fruits and …

3-Indolepropionic acid upturned male reproductive function by reducing oxido-inflammatory responses and apoptosis along the hypothalamic-pituitary-gonadal axis of …

SE Owumi, MT Otunla, UO Arunsi, ES Najophe - Toxicology, 2021 - Elsevier
We examined the effect of 3-Indolepropionic acid (3-IPA), an antioxidant on the
organophosphorus pesticide chlorpyrifos (CPF)-induced reproductive toxicity in rats. The …

Chlorogenic acid co‐administration abates tamoxifen‐mediated reproductive toxicities in male rats: an experimental approach

SE Owumi, RA Anaikor, UO Arunsi… - Journal of Food …, 2021 - Wiley Online Library
Reports over the years have demonstrated toxic side effect–including reproductive toxicity‐
of tamoxifen (TAM), a drug of choice in the management of primary breast cancer …

Protective role of m6A binding protein YTHDC2 on CCNB2 in manganese-induced spermatogenesis dysfunction

Z Qi, Y Liu, H Yang, X Yang, H Wang, B Liu… - Chemico-biological …, 2022 - Elsevier
Human infertility has become the third largest serious disease in the world, seriously
affecting the quality of human fertility. Studies have shown that manganese (Mn) can …

3-Indolepropionic acid prevented chlorpyrifos-induced hepatorenal toxicities in rats by improving anti-inflammatory, antioxidant, and pro-apoptotic responses and …

SE Owumi, ES Najophe, MT Otunla - Environmental science and pollution …, 2022 - Springer
The application of chlorpyrifos (CPF), an organophosphorus pesticide to control insects, is
associated with oxidative stress and reduced quality of life in humans and animals. Indole-3 …

Decrease in reproductive dysfunction using aflatoxin B1 exposure: a treatment with 3‐indolepropionic acid in albino Wistar rat

SE Owumi, MT Otunla, ES Najophe, AK Oyelere - Andrologia, 2022 - Wiley Online Library
We assessed the individual and combined consequence of 3‐indolepropionic acid on
aflatoxin B1‐induced reproductive toxicity in rats. The experimental cohorts were dosed for …