The cytochrome P450 mixed function oxidase enzymes play a major role in the metabolism
of important endogenous substrates as well as in the biotransformation of xenobiotics. The …

Biocatalytic reactions performed by cytochrome P450 monooxygenases are interesting in
pharmaceutical research since they are involved in human drug metabolism. Furthermore …

Steroidal C7β alcohols and their respective esters have shown significant promise as
neuroprotective and anti‐inflammatory agents to treat chronic neuronal damage like stroke …

Cytochrome P450 monooxygenases play a crucial role in the biosynthesis of many natural
products and in the human metabolism of numerous pharmaceuticals. This has inspired …

Multidimensional fitness landscapes provide insights into the molecular basis of laboratory
and natural evolution. To date, such efforts usually focus on limited protein families and a …

Abstract With only 1.3− 4.3% in total hepatic CYP content, human CYP2D6 can metabolize
more than 160 drugs. It is a highly polymorphic enzyme and subject to marked inhibition by …

Human enzymes have been widely studied in various disciplines. The number of reactions
taking place in the human body is vast, and so is the number of potential catalysts for …

To facilitate the wider application of the NADPH-dependent P450 BM3, we fused the
monooxygenase with a phosphite dehydrogenase (PTDH). The resulting monooxygenase …

The study of drug metabolism is fundamental to drug discovery and development (DDD)
since by mediating the clearance of most drugs, metabolic enzymes influence their …

Detailed understanding of the biotransformation of drugs into stable or reactive metabolites
is important during all stages of drug discovery and development. Structural characterization …