Human bodies collectively turn over about 200 billion to 300 billion cells every day. Such
turnover is an integral part of embryonic and postnatal development, as well as routine …

Oxidative stress results from the production of oxygen radicals in excess of the antioxidant
capacity of the stressed tissue. Many conditions or events associated with male infertility are …

Phagocytic removal of apoptotic cells occurs efficiently in vivo such that even in tissues with
significant apoptosis, very few apoptotic cells are detectable. This is thought to be due to the …

Mammalian spermatogenesis is a complex biological process occurring in the seminiferous
tubules in the testis. This process represents a delicate balance between cell proliferation …

Testicular torsion is a urological emergency most commonly seen in adolescence, involving
a decrease in blood flow in the testis resulting from torsion of the spermatic cord that can …

Summary TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases,
activated by their ligands GAS6 and PROS1. TAMs are necessary for adult homeostasis in …

This study investigates the role of neutrophils in ischemia-induced aspermatogenesis in the
mouse. Previous studies in the rat have demonstrated that ischemia-inducing testicular …

Apoptosis and the subsequent clearance of dying cells occurs throughout development and
adult life in many tissues. Failure to promptly clear apoptotic cells has been linked to many …

Purpose: We review the work of our laboratory in discovering the pathophysiological
mechanisms that underpin testicular response to testicular torsion. Evidence from animal …

This review will focus the roles of TNF-alpha, IL-1 alpha, and IL-1 beta in the mammalian
testis and in two testicular pathologies, testicular torsion and orchitis. TNF alpha in the testis …