Neuroinflammation precedes the clinical onset of various neurodegenerative diseases,
including Alzheimer's disease (AD), by years or frequently even decades (–). In terms of the …

Kinases are highly tractable drug targets that have reached unparalleled success in fields
such as cancer but whose potential has not yet been realized in neuroscience. There are …

Understanding cell-type-specific gene regulatory mechanisms from genetic variants to
diseases remains challenging. To address this, we developed a computational pipeline …

Alzheimer's is the neurodegenerative disease affecting the largest number of patients in the
world. In spite of the intense research of the last decades, progress about its knowledge and …

The tumor necrosis factor (TNF) superfamily (TNFSF) is a protein superfamily of type II
transmembrane proteins commonly containing the TNF homology domain. The superfamily …

Neuroinflammation is an important factor that exacerbates neuronal death and abnormal
synaptic function in neurodegenerative diseases (NDDs). Due to the complex pathogenesis …

Introduction The extracellular deposition of β-amyloid (Aβ) is a pathological hallmark in
Alzheimer's disease (AD), which induces microglial activation in the pathology of AD. The …

Cancer is becoming a global threat as its treatment accounts for many challenges. Hence,
newer inventions prioritize the requirement of developing novel anticancer agents. In this …

Microglial dysregulation, pertaining to impairment in phagocytosis, clearance and
containment of amyloid-β (Aβ), and activation of neuroinflammation, has been posited to …

Since the original description of Alzheimer´ s disease (AD), research into this condition has
mainly focused on assessing the alterations to neurons associated with dementia, and those …